Cochrane · systematic review · CD008817
Tacrolimus versus cyclosporin as primary immunosuppression for lung transplant recipients
Penninga, L, Penninga, EI, Møller, CH, et al. · Cochrane Database of Systematic Reviews · 2013 · Cochrane Library
Kidney and TransplantAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
7
current version
GRADE rated
7
No studies
0
Included studies
NR
No studies 0 · 0%Ungraded 0 · 0%Very low 0 · 0%Low 6 · 85.7%Moderate 1 · 14.3%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Tacrolimus compared to cyclosporin for lung transplant recipients
Population: Lung transplant recipients
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Mortality Mortality at latest Tacrolimus vs cyclosporin | RR 1.06 [0.75, 1.49] | 3 studies · 413 participants | Low Downgraded: risk of bias |
Acute rejection The number of patients who experienced at least one episode of rejection Tacrolimus vs cyclosporin | RR 0.89 [0.77, 1.05] | 2 studies · 323 participants | Low Downgraded: risk of bias |
Bronchiolitis obliterans syndrome The number of patients diagnosed with the bronchiolitis obliterans syndrome Tacrolimus vs cyclosporin | RR 0.46 [0.29, 0.74] | 3 studies · 413 participants | Moderate Downgraded: risk of bias |
Infection The number of overall infections per 100 patient days Tacrolimus vs cyclosporin | no estimate extracted | 1 study · 74 participants | Low Downgraded: risk of bias |
Treatment withdrawal the number of patients stopping the assigned drug intervention Tacrolimus vs cyclosporin | RR 0.27 [0.16, 0.46] | 3 studies · 413 participants | Low Downgraded: risk of bias |
Arterial hypertension Tacrolimus vs cyclosporin | RR 0.67 [0.5, 0.89] | 2 studies · 164 participants | Low Downgraded: risk of bias |
Diabetes mellitus Tacrolimus vs cyclosporin | RR 4.24 [1.58, 11.4] | 2 studies · 164 participants | Low Downgraded: risk of bias |