Cochrane · systematic review · CD012121
Carisbamate add‐on therapy for drug‐resistant focal epilepsy
Lu, C, Zheng, J, Cao, Y, et al. · Cochrane Database of Systematic Reviews · 2021 · Cochrane Library
EpilepsyAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
7
current version
GRADE rated
7
No studies
0
Included studies
NR
No studies 0 · 0%Ungraded 0 · 0%Very low 4 · 57.1%Low 2 · 28.6%Moderate 1 · 14.3%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Carisbamate compared to placebo for drug‐resistant focal epilepsy
Population: people with drug‐resistant focal epilepsy
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
50% or greater reduction in seizure frequency (responder rate) Carisbamate vs placebo | RR 1.36 [1.14, 1.62] | 4 studies · 2211 participants | Moderate Downgraded: risk of bias |
Seizure freedom Carisbamate vs placebo | RR 2.43 [0.84, 7.03] | 1 study · 540 participants | Very low Downgraded: risk of bias, imprecision |
Treatment withdrawal for any reason Carisbamate vs placebo | RR 1.32 [0.82, 2.12] | 4 studies · 2211 participants | Very low Downgraded: risk of bias, imprecision, inconsistency |
Treatment withdrawal due to adverse events Carisbamate vs placebo | RR 1.8 [0.78, 4.17] | 4 studies · 2211 participants | Very low Downgraded: risk of bias, imprecision, inconsistency |
Proportion of participants who experienced atleast 1 adverse event Carisbamate vs placebo | RR 1.1 [0.93, 1.3] | 2 studies · 1084 participants | Low Downgraded: risk of bias, inconsistency |
Adverse events: dizziness Carisbamate vs placebo | RR 2.06 [1.23, 3.44] | 4 studies · 2211 participants | Very low Downgraded: risk of bias, imprecision, inconsistency |
Adverse events: somnolence Carisbamate vs placebo | RR 1.82 [1.28, 2.58] | 4 studies · 2211 participants | Low Downgraded: risk of bias, imprecision |