Cochrane · systematic review · CD004184
Evening versus morning dosing regimen drug therapy for hypertension
Wu, C, Zhao, P, Xu, P, et al. · Cochrane Database of Systematic Reviews · 2024 · Cochrane Library
HypertensionAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
6
current version
GRADE rated
4
No studies
2
Included studies
NR
No studies 2 · 33.3%Ungraded 0 · 0%Very low 4 · 66.7%Low 0 · 0%Moderate 0 · 0%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Evening versus morning dosing regimen for the treatment of hypertension
Population: adults with primary (essential) hypertension whose systolic or diastolic (or both) blood pressure levels were 130/80 mmHg or greater
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
All‐cause mortality Evening vs morning dosing regimen | RR 0.49 [0.04, 5.42] | 1 study · 735 participants | Very low Downgraded: risk of bias, imprecision, inconsistency, indirectness, publication bias |
Cardiovascular mortality (time points not specified) Evening vs morning dosing regimen | no estimate extracted | NR | No studies |
Cardiovascular morbidity (stroke, myocardial infarction, congestive heart failure, aortic aneurysm) (time points not specified) Evening vs morning dosing regimen | no estimate extracted | NR | No studies |
Serious adverse events Evening vs morning dosing regimen | RR 1.17 [0.53, 2.57] | 2 studies · 833 participants | Very low Downgraded: risk of bias, imprecision, inconsistency, indirectness, publication bias |
Overall adverse events Evening vs morning dosing regimen | RR 0.89 [0.67, 1.2] | 7 studies · 1541 participants | Very low Downgraded: risk of bias, imprecision, inconsistency, indirectness, publication bias |
Withdrawals from treatment due to adverse events Evening vs morning dosing regimen | RR 0.76 [0.47, 1.23] | 7 studies · 1777 participants | Very low Downgraded: risk of bias, imprecision, inconsistency, indirectness, publication bias |