Cochrane · systematic review · CD002317
Tricyclic drugs for depression in children and adolescents
Hazell, P, Mirzaie, M · Cochrane Database of Systematic Reviews · 2013 · Cochrane Library
Common Mental DisordersAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
4
current version
GRADE rated
4
No studies
0
Included studies
NR
No studies 0 · 0%Ungraded 0 · 0%Very low 0 · 0%Low 4 · 100%Moderate 0 · 0%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Tricyclic antidepressants for depression in children and adolescents
Population: children and adolescents with depression
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Achieved recovery according to predetermined criteria (no longer meeting criteria for depression on K‐SADS or meeting a priori criteria for response on a depression checklist, assessed between 4 and 10 weeks of onset of treatment) | RR 1.07 [0.91, 1.26] | 9 studies · 453 participants | Low |
Change in depression checklist scores (BID, CDI, CDRS, DACL or HAM‐D from baseline to between 2 and 10 weeks) | no estimate extracted | 13 studies · 533 participants | Low |
Change in clinical global assessment scale scores (CGI scale or CGAS rated between 4 and 10 weeks of onset of treatment) | no estimate extracted | 5 studies · 180 participants | Low Downgraded: imprecision |
Number of withdrawals (occurring between 4 and 10 weeks of onset of treatment) | OR 1.65 [0.87, 3.14] | 8 studies · 462 participants | Low Downgraded: imprecision |