Pregabalin vs placebo: Withdrawals due to adverse events
- Population
- people with drug‐resistant focal epilepsy
- Intervention
- Pregabalin
- Comparison
- placebo
- Outcome
- Withdrawals due to adverse events
Pregabalin probably leads to higher treatment withdrawal due to adverse effects compared with placebo (moderate certainty).
What each review found
Include earlier review versions| Finding | Effect | Studies | GRADE certainty |
|---|---|---|---|
Pregabalin vs placebo Treatment withdrawal due to adverse effects · drug‐resistant focal epilepsy Pregabalin probably leads to higher treatment withdrawal due to adverse effects compared with placebo (moderate certainty). Pregabalin add‐on for drug‐resistant focal epilepsy (2022) · Cochrane Headline outcomes only | RR 2.6 [1.86, 3.64] | 9 studies · 2663 participants | Moderate |
Findings are shown side by side, never pooled across reviews.
The reviews
| Review | Searched up to | Included studies | AMSTAR 2 |
|---|---|---|---|
| Pregabalin add‐on for drug‐resistant focal epilepsy 2022 · Cochrane Headline outcomes only | Not reported | Not extracted | Not assessed |
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How reviews are matched to this question
Reviews word the same question differently. Four decision models (TypeSafe's Jev, Liquid AI's d1-ultra, SubQ Snap and Baseten's Elephant) judged each wording of the population, intervention, comparator and outcome against the others; two wordings count as the same when at least three of them agree and none clearly disagrees, and findings count as this question only when all four elements match. Timing, setting and subgroup never split a question: they are shown on each finding.