Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

57 questions · 60 findings · 27 reviews · Headline outcomes only

No studies found 9 · 15%GRADE not reported 0 · 0%Very low 12 · 20%Low 14 · 23.3%Moderate 13 · 21.7%High 12 · 20%

Surgery plus whole brain radiotherapy (WBRT) vs stereotactic radiosurgery

Overall survival · people with single or solitary brain metastasis

It is very uncertain whether surgery plus whole brain radiotherapy (WBRT) changes overall survival compared with stereotactic radiosurgery (very low certainty).

1 finding from 1 review

Surgery plus whole brain radiotherapy (WBRT) vs stereotactic radiosurgery plus WBRT

Overall survival · people with single or solitary brain metastasis

Surgery plus whole brain radiotherapy (WBRT) showed no clear difference in overall survival compared with stereotactic radiosurgery plus WBRT (low certainty).

1 finding from 1 review

Neoadjuvant chemotherapy prior to interval surgery (NACT) vs surgery followed by chemotherapy (PDS)

Overall survival ( · women with advanced ovarian epithelial cancer

Neoadjuvant chemotherapy prior to interval surgery (NACT) showed no clear difference in overall survival ( compared with surgery followed by chemotherapy (PDS) (high certainty).

1 finding from 1 review

iMRI image‐guided surgery vs surgery

Overall survival · high‐grade glioma

The review found no eligible studies for this question.

2 findings from 2 reviews · compare the 2 reviews

5‐ALA image‐guided surgery vs surgery

Overall survival · high‐grade glioma

The review found no eligible studies for this question.

2 findings from 2 reviews · compare the 2 reviews

Neuronavigation image‐guided surgery vs surgery

Overall survival · high‐grade glioma

The review found no eligible studies for this question.

2 findings from 2 reviews · compare the 2 reviews

Ultra‐radical (extensive) surgery vs surgery

Survival (overall and disease‐ specific) · women with stage IIIc or IV ovarian cancer

It is very uncertain whether ultra‐radical (extensive) surgery changes survival (overall and disease‐ specific) compared with standard surgery (very low certainty).

1 finding from 1 review

Whole brain radiation therapy (WBRT) + stereotactic radiosurgery (SRS) vs WBRT

Overall survival · Patients with brain metastases

Whole brain radiation therapy (WBRT) + stereotactic radiosurgery (SRS) showed no clear difference in overall survival compared with WBRT (moderate certainty).

1 finding from 1 review

Whole brain radiation therapy (WBRT) + stereotactic radiosurgery (SRS) vs WBRT

Overall survivalNo. of participants: 2631(8 RCTs) · patients with newly diagnosed multiple brain metastases

WBRT and radiosurgery showed no clear difference in overall survivalNo. of participants: 358(2 RCTs) compared with WBRT (moderate certainty).

1 finding from 1 review