Cochrane · systematic review · CD012939
De‐intensified adjuvant (chemo)radiotherapy versus standard adjuvant chemoradiotherapy post transoral minimally invasive surgery for resectable HPV‐positive oropharyngeal carcinoma
Howard, J, Dwivedi, RC, Masterson, L, et al. · Cochrane Database of Systematic Reviews · 2018 · Cochrane Library
ENTAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
8
current version
GRADE rated
0
No studies
8
Included studies
NR
No studies 8 · 100%Ungraded 0 · 0%Very low 0 · 0%Low 0 · 0%Moderate 0 · 0%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Low‐dose adjuvant radiotherapy versus standard‐dose adjuvant radiotherapy
Population: patients with HPV‐positive oropharyngeal carcinoma who have received minimally invasive transoral surgery
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Overall survival Low‐dose adjuvant radiotherapy vs standard‐dose adjuvant radiotherapy | no estimate extracted | NR | No studies |
Disease‐free survival Low‐dose adjuvant radiotherapy vs standard‐dose adjuvant radiotherapy | no estimate extracted | NR | No studies |
Swallowing ability Low‐dose adjuvant radiotherapy vs standard‐dose adjuvant radiotherapy | no estimate extracted | NR | No studies |
Voice (Voice Handicap Index) Low‐dose adjuvant radiotherapy vs standard‐dose adjuvant radiotherapy | no estimate extracted | NR | No studies |
Standard‐dose adjuvant radiotherapy alone versus adjuvant chemoradiotherapy
Population: patients with HPV‐positive oropharyngeal carcinoma who have received minimally invasive transoral surgery
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Overall survival Standard‐dose adjuvant radiotherapy alone vs adjuvant chemoradiotherapy | no estimate extracted | NR | No studies |
Disease‐free survival Standard‐dose adjuvant radiotherapy alone vs adjuvant chemoradiotherapy | no estimate extracted | NR | No studies |
Swallowing ability Standard‐dose adjuvant radiotherapy alone vs adjuvant chemoradiotherapy | no estimate extracted | NR | No studies |
Voice (Voice Handicap Index) Standard‐dose adjuvant radiotherapy alone vs adjuvant chemoradiotherapy | no estimate extracted | NR | No studies |