Cochrane · systematic review · CD012086
Surgery versus stereotactic radiotherapy for people with single or solitary brain metastasis
Fuentes, R, Osorio, D, Expósito Hernandez, J, et al. · Cochrane Database of Systematic Reviews · 2018 · Cochrane Library
Gynaecological, Neuro-oncology and Orphan CancerAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
10
current version
GRADE rated
9
No studies
1
Included studies
NR
No studies 1 · 10%Ungraded 0 · 0%Very low 7 · 70%Low 2 · 20%Moderate 0 · 0%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Surgery plus whole brain radiotherapy (WBRT) compared to stereotactic radiosurgery for people with single or solitary brain metastasis
Population: people with single or solitary brain metastasis
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Overall survival Surgery plus whole brain radiotherapy (WBRT) vs stereotactic radiosurgery | HR 0.92 [0.48, 1.77] | 1 study · 64 participants | Very low Downgraded: risk of bias, imprecision |
Adverse events Surgery plus whole brain radiotherapy (WBRT) vs stereotactic radiosurgery | RR 0.31 [0.07, 1.44] | 1 study · 64 participants | Very low Downgraded: risk of bias, imprecision |
Adverse events (moderate) Surgery plus whole brain radiotherapy (WBRT) vs stereotactic radiosurgery | RR 0.62 [0.11, 3.5] | 1 study · 64 participants | Very low Downgraded: risk of bias, imprecision |
Adverse events (severe) Surgery plus whole brain radiotherapy (WBRT) vs stereotactic radiosurgery | RR 0.13 [0, 2.5] | 1 study · 64 participants | Very low Downgraded: risk of bias, imprecision |
Progression‐free survival: not measured Surgery plus whole brain radiotherapy (WBRT) vs stereotactic radiosurgery | no estimate extracted | NR | No studies |
Quality of life (HRQoL) Surgery plus whole brain radiotherapy (WBRT) vs stereotactic radiosurgery | no estimate extracted | 1 study · 1 participants | Very low Downgraded: risk of bias, imprecision |
Surgery plus whole brain radiotherapy (WBRT) compared to stereotactic radiosurgery plus WBRT for people with single or solitary brain metastasis
Population: people with single or solitary brain metastasis
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Overall survival Surgery plus whole brain radiotherapy (WBRT) vs stereotactic radiosurgery plus WBRT | HR 0.53 [0.2, 1.42] | 1 study · 21 participants | Low Downgraded: imprecision |
Adverse events (moderate) Surgery plus whole brain radiotherapy (WBRT) vs stereotactic radiosurgery plus WBRT | RR 0.37 [0.05, 2.98] | 1 study · 21 participants | Very low Downgraded: risk of bias, imprecision |
Progression‐free survival Surgery plus whole brain radiotherapy (WBRT) vs stereotactic radiosurgery plus WBRT | RR 0.55 [0.22, 1.38] | 1 study · 21 participants | Low Downgraded: imprecision |
Quality of life (HRQoL) Surgery plus whole brain radiotherapy (WBRT) vs stereotactic radiosurgery plus WBRT | no estimate extracted | 1 study · 14 participants | Very low Downgraded: risk of bias, imprecision |