Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

62 questions · 62 findings · 30 reviews · Headline outcomes only

No studies found 15 · 24.2%GRADE not reported 1 · 1.6%Very low 32 · 51.6%Low 9 · 14.5%Moderate 5 · 8.1%High 0 · 0%

Prophylactic plasma transfusion before surgery/invasive procedures vs no prophylactic plasma transfusion before surgery/invasive procedures (colloid, crystalloid, placebo, or no treatment)

Serious adverse events measured by surgery or procedure‐related complications within 30 days ‐ not reported · patients undergoing non‐cardiac surgery/invasive procedures

The review found no eligible studies for this question.

1 finding from 1 review

Prophylactic plasma transfusion before surgery/invasive procedures vs alternative haemostatic agents

Serious adverse events measured by surgery or procedure‐related complications within 30 days ‐ not reported · patients undergoing non‐cardiac surgery/invasive procedures

The review found no eligible studies for this question.

1 finding from 1 review

Prophylactic plasma transfusion before surgery/invasive procedures vs no prophylactic plasma transfusion before surgery/invasive procedures (colloid, crystalloid, placebo, or no treatment)

Serious adverse events measured by plasma transfusion‐related complications within 24 hours № of participants: 21 (1 RCT) · patients undergoing non‐cardiac surgery/invasive procedures
1 finding from 1 review

Prophylactic plasma transfusion before surgery/invasive procedures vs alternative haemostatic agents

Serious adverse events measured by plasma transfusion‐related complications within 24 hours № of participants: 21 (1 RCT) · patients undergoing non‐cardiac surgery/invasive procedures

It is very uncertain whether prophylactic plasma transfusion before surgery/invasive procedures changes serious adverse events measured by plasma transfusion‐related… compared with alternative haemostatic agents (very low certainty).

1 finding from 1 review

Thromboelastography threshold vs standard of care (laboratory parameters)

Serious adverse events measured by surgery or procedure‐related complications within 30 days ‐ not reported · patients undergoing non‐cardiac surgery/invasive procedures

The review found no eligible studies for this question.

1 finding from 1 review

Summary of findings. Surgery (percutaneous wire fixation) vs not surgery (cast only)

Serious adverse events (typically more serious complications) ( · children with displaced distal radius fracture with intact or involved or displaced ulna fracture (both‐bone fracture)

It is very uncertain whether summary of findings. Surgery (percutaneous wire fixation) changes serious adverse events (typically more serious complications) ( compared with not surgery (cast only) (very low certainty).

1 finding from 1 review

Prophylactic platelet transfusion prior to surgery vs alternative treatment

Serious adverse events (transfusion‐related adverse effects within 24 hours of the transfusion) · people with a low platelet count

It is very uncertain whether prophylactic platelet transfusion prior to surgery changes serious adverse events (transfusion‐related adverse effects within… compared with alternative treatments (very low certainty).

1 finding from 1 review

Summary of findings table ‐ Deep neuromuscular blockade (NMB) vs moderate NMB

Serious adverse events (SAEs) start of surgery until 8 hours after surgery · adults undergoing intra‐ and transperitoneal laparoscopic procedures

It is very uncertain whether summary of findings table ‐ Deep neuromuscular blockade (NMB) changes serious adverse events (SAEs) start of surgery until 8 hours after… compared with moderate NMB (very low certainty).

1 finding from 1 review

Early dressing removal vs delayed dressing removal

Serious adverse events Patients experiencing serious adverse events within 30 days of surgery · people with surgical site infection

It is very uncertain whether early dressing removal changes serious adverse events Patients experiencing serious adverse events… compared with delayed dressing removal (very low certainty).

1 finding from 1 review

Bioengineered devices vs standard techniques

Specific serious adverse events: further surgery (device removal or revision)i assessed as: any unplanned secondary surgery to remove device · people undergoing peripheral nerve repair of the upper limb

It is very uncertain whether bioengineered devices changes specific serious adverse events: further surgery (device removal or… compared with standard techniques (very low certainty).

1 finding from 1 review

Enhanced recovery protocol vs usual care

Serious adverse events (number) · people with major upper gastrointestinal, liver and pancreatic surgery

It is very uncertain whether enhanced recovery protocol changes serious adverse events (number) compared with standard care (very low certainty).

1 finding from 1 review