Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

270 questions · 281 findings · 119 reviews · Headline outcomes only

No studies found 53 · 18.9%GRADE not reported 16 · 5.7%Very low 81 · 28.8%Low 75 · 26.7%Moderate 39 · 13.9%High 17 · 6%

Lower blood pressure targets vs standard blood pressure targets

Total serious adverse events · cardiovascular disease with high blood pressure

Lower blood pressure targets showed no clear difference in total serious adverse events compared with standard blood pressure targets (low certainty).

1 finding from 1 review

Antidepressants vs placebo

Serious adverse events between 0 and 16 weeks · predominantly knee osteoarthritis

Antidepressant showed no clear difference in serious adverse events between 0 and 16 weeks compared with placebo (low certainty).

1 finding from 1 review

Pregabalin vs placebo at end of treatment

Serious adverse events · patients with fibromyalgia

Pregabalin showed no clear difference in serious adverse events compared with placebo at end of treatment (moderate certainty).

1 finding from 1 review