What do systematic reviews say?

Tramadol in combination with acetaminophen vs placebo

• Tramadol for osteoarthritis 2019 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 15 participants
  Low

Tramadol in combination with acetaminophen vs NSAIDs

• Tramadol for osteoarthritis 2019 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 15 participants
  Low

Tramadol in combination with acetaminophen vs other opioids

The review found no eligible studies for this question.

• Tramadol for osteoarthritis 2019 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

N‐acetylcysteine vs placebo

The review found no eligible studies for this question.

• N‐acetylcysteine for non‐paracetamol (acetaminophen)‐related acute liver failure 2020 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

N‐acetylcysteine vs placebo

N‐acetylcysteine showed no clear difference in serious adverse events compared with placebo (low certainty).

• N‐acetylcysteine for non‐paracetamol (acetaminophen)‐related acute liver failure 2020 · Cochrane Headline outcomes only
  RR 1.25 [0.35, 4.51]
  1 study · 184 participants
  Low

N‐acetylcysteine vs placebo

N‐acetylcysteine showed no clear difference in non‐serious adverse events compared with placebo (low certainty).

• N‐acetylcysteine for non‐paracetamol (acetaminophen)‐related acute liver failure 2020 · Cochrane Headline outcomes only
  RR 1.19 [0.62, 2.16]
  1 study · 184 participants
  Low

N‐acetylcysteine vs placebo

N‐acetylcysteine showed no clear difference in non‐serious adverse events compared with placebo (low certainty).

• N‐acetylcysteine for non‐paracetamol (acetaminophen)‐related acute liver failure 2020 · Cochrane Headline outcomes only
  RR 1.07 [0.79, 1.45]
  1 study · 173 participants
  Low

Intervention not reported

• Oral paracetamol (acetaminophen) for cancer pain 2017 · Cochrane Headline outcomes only
  no estimate extracted
  3 studies · 93 participants
  Very low

Paracetamol 500 mg to 650 mg vs placebo

• Paracetamol (acetaminophen) for acute treatment of episodic tension‐type headache in adults 2016 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  Very low

Paracetamol 1000 mg vs placebo

• Paracetamol (acetaminophen) for acute treatment of episodic tension‐type headache in adults 2016 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  Moderate

Paracetamol alone, paracetamol plus codeine, or paracetamol plus dihydrocodeine vs placebo

• Paracetamol (acetaminophen) with or without codeine or dihydrocodeine for neuropathic pain in adults 2016 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  Very low

Intervention not reported

• Codeine, alone and with paracetamol (acetaminophen), for cancer pain 2014 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  Very low

Oral tramadol vs oral morphine

• Tramadol with or without paracetamol (acetaminophen) for cancer pain 2017 · Cochrane Headline outcomes only
  no estimate extracted
  2 studies · 280 participants
  Very low

Tramadol vs paracetamol

The review found no eligible studies for this question.

• Tramadol for osteoarthritis 2019 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found