What do systematic reviews say?

Wax (fluid wax), two stage-two step selective pressure final impression vs Polysulfide rubber (elastomer)

The review found no eligible studies for this question.

• Final‐impression techniques and materials for making complete and removable partial dentures 2018 · Cochrane All outcomes
  Not measured
  0 studies
  No studies found

Biofunctional Prosthetic System (BPS): closed-mouth two stage-two step final impression with addition silicone elastomer vs Conventional complete denture technique (CCD): open-mouth two stage-two step conventional technique using elastomer

• Final‐impression techniques and materials for making complete and removable partial dentures 2018 · Cochrane All outcomes

  3 months
  OHIP-EDENT median scores: BPS 34.5; CCD 35.8. No clear difference between groups
  1 study · 10 participants
  Very low

Single-stage alginate impression (simplified method) vs Two stage-two step zinc-oxide eugenol (ZoE) traditional method

It is very uncertain whether single-stage alginate impression (simplified method) changes participant-reported oral health-related quality of life (OHIP-EDENT) compared with two stage-two step zinc-oxide eugenol (ZoE) traditional method (very low certainty).

• Final‐impression techniques and materials for making complete and removable partial dentures 2018 · Cochrane All outcomes

  6 months
  MD 0.5 [-2.67, 3.67]
  1 study · 39 participants
  Very low

Single-stage alginate impression (simplified method) vs Two stage-two step elastomer (silicone, polysulfide, or polyether) conventional method

It is very uncertain whether single-stage alginate impression (simplified method) changes participant-reported oral health-related quality of life (OHIP-EDENT) compared with two stage-two step elastomer (silicone, polysulfide, or polyether)… (very low certainty).

• Final‐impression techniques and materials for making complete and removable partial dentures 2018 · Cochrane All outcomes

  1 month
  MD 0.05 [-2.37, 2.47]
  2 studies · 98 participants
  Very low

Selenium vs no intervention

• Pharmacological interventions for preventing dry mouth and salivary gland dysfunction following radiotherapy 2017 · Cochrane All outcomes

  6 weeks after end of RT
  Insufficient evidence of differences for loss of taste or dysphagia; data largely unusable (no standard deviations). Ageusia milder in selenium group (not significant); dysphagia significant only at week 7 (P = 0.05)…
  1 study
  GRADE not reported

Malocclusion vs No malocclusion

Malocclusions probably have a negative effect on OHRQoL in adolescents, after adjustment for confounders (moderate certainty).

• Malocclusions and quality of life among adolescents: a systematic review and meta-analysis. 2023 All outcomes

  Schools and dental clinics (multiple countries)
  Impaired OHRQoL, qualitative synthesis: relative effect not estimable across the 13 studies (13,864 participants); moderate quality of evidence (GRADE).
  13 studies · 13864 participants
  Moderate

Alginate (two stage-two step final/wash impression) vs Silicone elastomer (two stage-two step)

Alginate (two stage-two step final/wash impression) may leads to higher participant-reported oral health-related quality of life… compared with silicone elastomer (two stage-two step) (low certainty).

• Final‐impression techniques and materials for making complete and removable partial dentures 2018 · Cochrane All outcomes

  2 weeks
  MD 7.20 [2.71, 11.69]
  1 study · 144 participants
  Low

Antioxidants (lycopene, curcumin, Oxitard) vs Placebo or no active treatment

The review found no eligible studies for this question.

• Interventions for managing oral submucous fibrosis 2024 · Cochrane All outcomes
  The trials did not measure quality of life.
  0 studies
  No studies found

Chemotherapy (any regimen; added to, or compared with, locoregional treatment) vs Locoregional treatment and/or an alternative chemotherapy regimen

The review found no eligible studies for this question.

• Interventions for the treatment of oral cavity and oropharyngeal cancer: chemotherapy 2021 · Cochrane All outcomes
  Quality of life was a planned (protocol) outcome but no included trial provided usable quality-of-life data; the protocol was modified to report only survival/response outcomes.
  0 studies
  No studies found

EGFR monoclonal antibody (cetuximab or nimotuzumab) plus standard therapy (radiotherapy or chemoradiotherapy) vs Standard therapy alone (radiotherapy or chemoradiotherapy)

• Interventions for the treatment of oral and oropharyngeal cancers: targeted therapy and immunotherapy 2015 · Cochrane All outcomes

  24 to 70 months
  Only one study (Bonner 2006, 424 participants) comprehensively assessed quality of life using EORTC QLQ-C30 (v3.0) and QLQ-H&N35; no statistically significant difference between groups for global health status or any…
  1 study · 424 participants
  GRADE not reported

Interferon-alpha (topical lozenges) vs placebo

• Interventions for managing oral ulcers in Behçet's disease 2014 · Cochrane All outcomes
  Kilic 2009 described the use of a quality of life assessment tool but did not report any quality of life data.
  1 study · 84 participants
  GRADE not reported

Phenytoin mouthrinse vs placebo

Phenytoin mouthrinse led to lower quality of life compared with placebo; GRADE not reported.

• Interventions for treating oral mucositis for patients with cancer receiving treatment 2010 · Cochrane All outcomes

  7 days
  MD -15.10 [-26.04, -4.16]
  1 study · 12 participants
  GRADE not reported

Radiotherapy (morning) vs Afternoon radiotherapy

• Interventions for the treatment of oral cavity and oropharyngeal cancer: radiotherapy 2010 · Cochrane All outcomes
  Bjarnason 2009: no statistically significant difference in quality of life scores (data not reported). Morning radiotherapy was associated with significantly less weight loss after 5 months.
  1 study · 216 participants
  GRADE not reported

Pre-radiotherapy extraction of healthy molar teeth vs Conservative treatment (leaving the teeth in place during radiotherapy, with oral health education and disease prevention: oral hygiene, fluoride, diet advice)

The review found no eligible studies for this question.

• Dental extractions prior to radiotherapy to the jaws for reducing post‐radiotherapy dental complications 2013 · Cochrane All outcomes
  no estimate extracted
  0 studies
  No studies found

Pre-radiotherapy extraction of diseased molar teeth vs Conservative treatment (restoration of the teeth and leaving them in place during radiotherapy, with oral health education and disease prevention: oral hygiene, fluoride, diet advice)

The review found no eligible studies for this question.

• Dental extractions prior to radiotherapy to the jaws for reducing post‐radiotherapy dental complications 2013 · Cochrane All outcomes
  no estimate extracted
  0 studies
  No studies found

CBT vs alternative treatment

The review found no eligible studies for this question.

• Psychological therapies for temporomandibular disorders (TMDs) 2022 · Cochrane All outcomes
  This outcome was not measured (not synthesised for this comparison; review-wide only one study reported quality of life).
  Studies not reported
  No studies found

Mechanical tongue cleaning (tongue scraper) vs No tongue cleaning

The review found no eligible studies for this question.

• Interventions for managing halitosis 2019 · Cochrane All outcomes
  Quality of life was a prespecified secondary outcome. None of the 44 included studies in the review (across all comparisons) reported quality-of-life data (review-wide evidence gap).
  0 studies
  No studies found

NSAIDs vs oral progestogens (control)

The review found no eligible studies for this question.

• Non‐steroidal anti‐inflammatory drugs for heavy menstrual bleeding 2019 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

NSAIDs vs oral contraceptive pill (control)

The review found no eligible studies for this question.

• Non‐steroidal anti‐inflammatory drugs for heavy menstrual bleeding 2019 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Manipulation (cervical) vs oral medicine

The review found no eligible studies for this question.

• Manipulation and mobilisation for neck pain contrasted against an inactive control or another active treatment 2015 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found