Findings

What do systematic reviews say?

140 questions · 142 findings · 71 reviews

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No studies found 55 · 38.7%GRADE not reported 13 · 9.2%Very low 19 · 13.4%Low 29 · 20.4%Moderate 23 · 16.2%High 3 · 2.1%

High‐dose vs low‐dose coenzyme Q10 and vitamin E

Longer‐term (minimum 1 month) change in generic quality of life scores · people with speech disorder resulting from hereditary ataxias

1 finding from 1 review

Treatment for speech disorder in Friedreich ataxia and other hereditary ataxia syndromes 2014 · Cochrane Headline outcomes only
no estimate extracted
0 studies · 0 participants
GRADE not reported

Buspirone vs placebo

Longer‐term (minimum 1 month) change in generic quality of life scores · people with speech disorder resulting from hereditary ataxias

1 finding from 1 review

Treatment for speech disorder in Friedreich ataxia and other hereditary ataxia syndromes 2014 · Cochrane Headline outcomes only
no estimate extracted
0 studies · 0 participants
GRADE not reported

Varenicline vs placebo

Generic quality of life measures · people with speech disorder resulting from hereditary ataxias

1 finding from 1 review

Treatment for speech disorder in Friedreich ataxia and other hereditary ataxia syndromes 2014 · Cochrane Headline outcomes only
no estimate extracted
1 study · 13 participants
Very low

EHealth interventions vs any comparator

Quality of life (0 to < 1 week postintervention) measured using different scales across studies · children and adolescents, aged 10 to 18 years, with long‐term physical conditions

1 finding from 1 review

E‐Health interventions for anxiety and depression in children and adolescents with long‐term physical conditions 2018 · Cochrane Headline outcomes only
no estimate extracted
1 study · 34 participants
Very low

CBT plus standard care vs usual care

Quality of life: 1. General quality of life · patients with schizophrenia

1 finding from 1 review

Cognitive behavioural therapy plus standard care versus standard care for people with schizophrenia 2018 · Cochrane Headline outcomes only
no estimate extracted
1 study · 71 participants
Very low

Endoscopy vs surgery

Health‐related quality of life (mental) · participants with painful obstructive chronic pancreatitis

1 finding from 1 review

Endoscopic or surgical intervention for painful obstructive chronic pancreatitis 2015 · Cochrane Headline outcomes only
no estimate extracted
1 study · 31 participants
Moderate

Endoscopy vs surgery

Quality of Life: SF‐36 (physical component) · participants with painful obstructive chronic pancreatitis

1 finding from 1 review

Endoscopic or surgical intervention for painful obstructive chronic pancreatitis 2015 · Cochrane Headline outcomes only
no estimate extracted
1 study · 31 participants
Moderate

Oral hygiene interventions (mechanical plaque removal): knowledge-based, behavioural, or skills training for people with ID or their carers vs Usual care, no care, or a similar alternative intervention

Quality of life changes or long-term, patient-centred outcomes (e.g. tooth retention) · People with intellectual disabilities (ID), living at home, in day care, in hospital or in a residential care setting; all levels of ID as…

The review found no eligible studies for this question.

1 finding from 1 review

Oral hygiene interventions for people with intellectual disabilities 2019 · Cochrane All outcomes
No studies measured quality of life changes or long-term, patient-centred outcomes as formal outcomes; some studies commented on quality of life only in the discussion or conclusion sections.
0 studies
No studies found

Mosaicplasty vs microfracture

QoL · Adults with isolated cartilage defects (defect areas 1.0 cm2 to 6.0 cm2) of the knee

It is very uncertain whether mosaicplasty changes quality of life: long‐term KOOS QOL score. Scale 0 to 100; higher… compared with microfracture (very low certainty).

1 finding from 1 review

Surgical interventions (microfracture, drilling, mosaicplasty, and allograft transplantation) for treating isolated… 2016 · Cochrane Headline outcomes only
no estimate extracted
1 study · 25 participants
Very low

Azelaic acid vs adapalene

Secondary outcome: Dermatology Quality of Life measure · participants with acne

1 finding from 1 review

Topical azelaic acid, salicylic acid, nicotinamide, sulphur, zinc and fruit acid (alpha‐hydroxy acid) for acne 2020 · Cochrane Headline outcomes only
no estimate extracted
1 study · 55 participants
Very low

Group B cognitive behavioural therapy: cognitive behavioural therapy + supportive therapy vs supportive therapy

Quality of Life Manchester Short Assessment (MANSA) · people in the prodromal stage of psychosis

1 finding from 1 review

Interventions for prodromal stage of psychosis 2019 · Cochrane Headline outcomes only
no estimate extracted
1 study · 140 participants
Very low

Group B cognitive behavioural therapy: cognitive behavioural therapy (specific preventive intervention) + needs‐based intervention + risperidone vs needs‐based intervention

QoL · people in the prodromal stage of psychosis

1 finding from 1 review

Interventions for prodromal stage of psychosis 2019 · Cochrane Headline outcomes only
no estimate extracted
1 study · 40 participants
Very low

Betamethasone vs placebo

Generic quality of life measures · people with speech disorder resulting from hereditary ataxias

1 finding from 1 review

Treatment for speech disorder in Friedreich ataxia and other hereditary ataxia syndromes 2014 · Cochrane Headline outcomes only
no estimate extracted
0 studies · 0 participants
GRADE not reported

BRIEF FAMILY INTERVENTION vs usual care

Quality of life/satisfaction with care ‐ for recipients or carers ‐ medium to long term ‐ not reported · patients with schizophrenia

The review found no eligible studies for this question.

1 finding from 1 review

Family intervention (brief) for schizophrenia 2014 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Neurodynamic mobilisation vs no treatment

Long‐term improvement in functional ability or health‐related quality of life (more than three months) · People with carpal tunnel syndrome on a waiting list for carpal tunnel release

1 finding from 1 review

Exercise and mobilisation interventions for carpal tunnel syndrome 2012 · Cochrane Headline outcomes only
no estimate extracted
1 study · 14 participants
Very low

Individual TF‐CBT vs Brief PTSD psychoeducation

Quality of life: 1. General quality of life · Adults with co‐morbid PTSD and SMI

1 finding from 1 review

Psychological interventions for post‐traumatic stress disorder (PTSD) in people with severe mental illness 2017 · Cochrane Headline outcomes only
no estimate extracted
1 study · 49 participants
Low

Surgery vs splint

Health‐related quality of life (EQ‐5D) ‐ Long‐term improvement: > 3 months Scale: 0 to 1, higher is better · carpal tunnel syndrome

1 finding from 1 review

Surgical versus non‐surgical treatment for carpal tunnel syndrome 2024 · Cochrane Headline outcomes only
no estimate extracted
1 study · 167 participants
Low

Humour‐based interventions vs usual care

Quality of life: clinically important change in quality of life · patients with schizophrenia

The review found no eligible studies for this question.

1 finding from 1 review

Humour‐based interventions for people with schizophrenia 2021 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Humour‐based interventions vs active control

Quality of life: clinically important change in quality of life · patients with schizophrenia

The review found no eligible studies for this question.

1 finding from 1 review

Humour‐based interventions for people with schizophrenia 2021 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

α‐tocopheryl quinone vs placebo

Longer‐term (minimum 1 month) change in generic quality of life scores · people with speech disorder resulting from hereditary ataxias

1 finding from 1 review

Treatment for speech disorder in Friedreich ataxia and other hereditary ataxia syndromes 2014 · Cochrane Headline outcomes only
no estimate extracted
1 study · 19 participants
Moderate