Cochrane · systematic review · CD010675
Surgical interventions (microfracture, drilling, mosaicplasty, and allograft transplantation) for treating isolated cartilage defects of the knee in adults
Gracitelli, GC, Moraes, VY, Franciozi, CES, et al. · Cochrane Database of Systematic Reviews · 2016 · Cochrane Library
Bone, Joint and Muscle TraumaAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
7
current version
GRADE rated
7
No studies
0
Included studies
NR
No studies 0 · 0%Ungraded 0 · 0%Very low 7 · 100%Low 0 · 0%Moderate 0 · 0%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Mosaicplasty compared with microfracture for adults with isolated cartilage defects of the knee
Population: Adults with isolated cartilage defects (defect areas 1.0 cm2 to 6.0 cm2) of the knee
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Function (all scores/instruments): intermediate term IKDC 2000 (version) score. Scale from: 0 to 100; higher scores = better function. Mosaicplasty vs microfracture | MD 10.29 [7.87, 12.71] | 1 study · 57 participants | Very low Downgraded: risk of bias, inconsistency, indirectness |
Function (all scores/instruments): long term Scale from: 0 to 100; higher scores = better function. Mosaicplasty vs microfracture | no estimate extracted | 2 studies · 72 participants | Very low Downgraded: risk of bias, imprecision, inconsistency |
Quality of life: long‐term KOOS QOL score. Scale 0 to 100; higher scores = better QOL Mosaicplasty vs microfracture | no estimate extracted | 1 study · 25 participants | Very low Downgraded: risk of bias, imprecision, inconsistency, indirectness |
Failure of treatment and adverse effects: long‐term Participants with surgery and symptom recurrence Mosaicplasty vs microfracture | RR 0.47 [0.24, 0.9] | 3 studies · 129 participants | Very low Downgraded: risk of bias, imprecision, inconsistency, indirectness |
Pain: long‐term KOOS Pain score. Scale 0 to 100; higher scores = less pain Mosaicplasty vs microfracture | no estimate extracted | 1 study · 25 participants | Very low Downgraded: risk of bias, imprecision, inconsistency, indirectness |
Activity: intermediate term (1 to 5 years Mosaicplasty vs microfracture | MD 0.48 [0.21, 0.75] | 1 study · 57 participants | Very low Downgraded: risk of bias, inconsistency, indirectness |
Activity: long term (5 or more years Mosaicplasty vs microfracture | MD 0.2 [0.46, 0.98] | 1 study · 25 participants | Very low Downgraded: risk of bias, imprecision, inconsistency, indirectness |