Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

25 questions · 25 findings · 15 reviews · Pregnancy and Childbirth

No studies found 0 · 0%GRADE not reported 0 · 0%Very low 3 · 12%Low 13 · 52%Moderate 6 · 24%High 3 · 12%

Calcium supplementation/fortification vs placebo or no intervention

Gestational age (preterm birth < 37 weeks) · healthy pregnant women receiving calcium supplementation vs placebo or no treatment

Calcium supplementation showed no clear difference in preterm birth (a) Birth prior to 37 weeks compared with placebo or no treatment (maternal outcomes) (moderate certainty).

1 finding from 1 review

Calcium supplementation/fortification vs placebo or no intervention

Preterm birth less than 34 weeks' gestation · healthy pregnant women receiving calcium supplementation vs placebo or no treatment

Calcium supplementation showed no clear difference in preterm birth (b) Birth prior to 34 weeks compared with placebo or no treatment (maternal outcomes) (moderate certainty).

1 finding from 1 review

Any supplement containing iodine vs same supplement without iodine or no treatment/placebo (maternal outcomes)

Preterm birth · women during the preconception, pregnancy and postpartum period

Any supplement containing iodine showed no clear difference in preterm birth compared with same supplement without iodine or no treatment/placebo (maternal… (low certainty).

1 finding from 1 review

Summary of findings table ‐ Vitamin B12 supplementation vs no supplementation or placebo

Preterm birth · pregnant women

Summary of findings table ‐ Vitamin B12 supplementation showed no clear difference in preterm birth (< 37 weeks) compared with placebo/no vitamin B12 supplementation (low certainty).

1 finding from 1 review

Intramuscular (IM) progesterone vs no treatment or placebo

Preterm birth less than 34 weeks' gestation · Women with a multiple pregnancy

Intramuscular (IM) progesterone may leads to higher preterm birth less than 34 weeks compared with no treatment or placebo (low certainty).

1 finding from 1 review

Intramuscular (IM) progesterone vs no treatment or placebo

Preterm birth less than 28 weeks · Women with a multiple pregnancy

Intramuscular (IM) progesterone showed no clear difference in preterm birth less than 28 weeks compared with no treatment or placebo (moderate certainty).

1 finding from 1 review

Acupuncture vs placebo

Preterm birth · Pregnant women with hyperemesis gravidarum

Acupuncture showed no clear difference in preterm birth less than 37 weeks compared with placebo (low certainty).

1 finding from 1 review