Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

19 questions · 19 findings · 12 reviews · Neonatal

No studies found 1 · 5.3%GRADE not reported 0 · 0%Very low 2 · 10.5%Low 11 · 57.9%Moderate 4 · 21.1%High 1 · 5.3%

Bubble vs ventilator or Infant Flow Driver nasal continuous positive airway pressure (CPAP)

Pneumothorax · preterm infants receiving nasal CPAP

Bubble showed no clear difference in pneumothorax compared with ventilator or Infant Flow Driver nasal continuous positive airway… (low certainty).

1 finding from 1 review

Early vs late continuous positive airway pressure (CPAP)

Pulmonary air leak defined as pneumothorax · preterm infants with respiratory distress for initial respiratory support

Early showed no clear difference in air leak (pneumothorax) compared with late continuous positive airway pressure (CPAP) (low certainty).

1 finding from 1 review

Surfactant treatment guided by rapid tests for surfactant deficiency vs surfactant therapy provided to preterm infants with respiratory distress syndrome diagnosed on clinical and radiologic criteria

Pneumothorax · preterm infants at risk of respiratory distress syndrome

Surfactant treatment guided by rapid tests for surfactant deficiency showed no clear difference in any pneumothorax№ of participants: 506(2 RCTs) compared with surfactant therapy provided to preterm infants with respiratory… (low certainty).

1 finding from 1 review

Bovine lung lavage surfactant extract vs modified bovine minced lung surfactant extract

Pneumothorax · Preterm infants for treatment of RDS

Bovine lung lavage surfactant extract showed no clear difference in pneumothorax compared with modified bovine minced lung surfactant extract (low certainty).

1 finding from 1 review

Modified bovine minced lung surfactant extract vs porcine minced lung surfactant extract

Pneumothorax · Preterm infants for treatment of RDS

Modified bovine minced lung surfactant extract showed no clear difference in pneumothorax compared with porcine minced lung surfactant extract (low certainty).

1 finding from 1 review

Modified bovine minced lung surfactant extract vs porcine lung lavage surfactant

Pneumothorax · Preterm infants for treatment of RDS

Modified bovine minced lung surfactant extract leads to lower pneumothorax compared with porcine lung lavage surfactant (high certainty).

1 finding from 1 review

Bovine lung lavage surfactant extract vs modified bovine minced lung surfactant extract

Pneumothorax · Preterm infants for prevention of RDS

Bovine lung lavage surfactant extract showed no clear difference in pneumothorax. compared with modified bovine minced lung surfactant extract (moderate certainty).

1 finding from 1 review