Cochrane · systematic review · CD002975
Early versus delayed continuous positive airway pressure (CPAP) for respiratory distress in preterm infants
Ho, JJ, Subramaniam, P, Sivakaanthan, A, et al. · Cochrane Database of Systematic Reviews · 2020 · Cochrane Library
NeonatalAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
5
current version
GRADE rated
3
No studies
2
Included studies
NR
No studies 2 · 40%Ungraded 0 · 0%Very low 2 · 40%Low 1 · 20%Moderate 0 · 0%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Early compared to late continuous positive airway pressure (CPAP) for respiratory distress in preterm infants
Population: preterm infants with respiratory distress
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Use of IPPV before discharge Early vs late continuous positive airway pressure (CPAP) | RR 0.77 [0.43, 1.38] | 4 studies · 119 participants | Very low Downgraded: risk of bias |
Mortality (time not specified) Early vs late continuous positive airway pressure (CPAP) | no estimate extracted | NR | No studies |
Failure of treatment ‐ death or intermittent positive‐pressure ventilation (IPPV) before hospital discharge Early vs late continuous positive airway pressure (CPAP) | no estimate extracted | NR | No studies |
Air leak (pneumothorax) Early vs late continuous positive airway pressure (CPAP) | RR 1.09 [0.39, 3.04] | 3 studies · 98 participants | Low Downgraded: risk of bias, imprecision, indirectness |
Bronchopulmonary dysplasia at 36 weeks' postmenstrual age Early vs late continuous positive airway pressure (CPAP) | RR 1.42 [0.1, 20.49] | 1 study · 29 participants | Very low Downgraded: risk of bias, imprecision, indirectness |