Cochrane · systematic review · CD013158
Surfactant therapy guided by tests for lung maturity in preterm infants at risk of respiratory distress syndrome
Sibrecht, G, Kearl, CR, Borys, F, et al. · Cochrane Database of Systematic Reviews · 2023 · Cochrane Library
NeonatalAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
7
current version
GRADE rated
4
No studies
3
Included studies
NR
No studies 3 · 42.9%Ungraded 0 · 0%Very low 1 · 14.3%Low 3 · 42.9%Moderate 0 · 0%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Surfactant treatment guided by rapid tests for surfactant deficiency versus surfactant therapy provided to preterm infants with respiratory distress syndrome diagnosed on clinical and radiologic criteria
Population: preterm infants at risk of respiratory distress syndrome
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Neonatal mortality (mortality < 28 days of age) from any cause ‐ not reported Surfactant treatment guided by rapid tests for surfactant deficiency vs surfactant therapy provided to preterm infants with respiratory distress syndrome diagnosed on clinical and radiologic criteria | no estimate extracted | NR | No studies |
Mortality prior to hospital discharge№ of participants: 562 (3 RCTs) Surfactant treatment guided by rapid tests for surfactant deficiency vs surfactant therapy provided to preterm infants with respiratory distress syndrome diagnosed on clinical and radiologic criteria | RR 1.25 [0.65, 2.41] | NR | Very low Downgraded: inconsistency |
Bronchopulmonary dysplasia№ of participants: 562(3 RCTs) Surfactant treatment guided by rapid tests for surfactant deficiency vs surfactant therapy provided to preterm infants with respiratory distress syndrome diagnosed on clinical and radiologic criteria | RR 0.9 [0.61, 1.32] | NR | Low |
Bronchopulmonary dysplasia or mortality ‐ not reported Surfactant treatment guided by rapid tests for surfactant deficiency vs surfactant therapy provided to preterm infants with respiratory distress syndrome diagnosed on clinical and radiologic criteria | no estimate extracted | NR | No studies |
Surfactant utilization № of participants: 562 (3 RCTs) Surfactant treatment guided by rapid tests for surfactant deficiency vs surfactant therapy provided to preterm infants with respiratory distress syndrome diagnosed on clinical and radiologic criteria | RR 0.97 [0.85, 1.11] | NR | Low Downgraded: inconsistency |
Any pneumothorax№ of participants: 506(2 RCTs) Surfactant treatment guided by rapid tests for surfactant deficiency vs surfactant therapy provided to preterm infants with respiratory distress syndrome diagnosed on clinical and radiologic criteria | RR 0.53 [0.15, 1.92] | NR | Low |
Neurodevelopmental outcome at approximately two years' corrected age ‐ not reported Surfactant treatment guided by rapid tests for surfactant deficiency vs surfactant therapy provided to preterm infants with respiratory distress syndrome diagnosed on clinical and radiologic criteria | no estimate extracted | NR | No studies |