Cochrane · systematic review · CD010249
Comparison of animal‐derived surfactants for the prevention and treatment of respiratory distress syndrome in preterm infants
Singh, N, Halliday, HL, Stevens, TP, et al. · Cochrane Database of Systematic Reviews · 2015 · Cochrane Library
NeonatalAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
35
current version
GRADE rated
23
No studies
12
Included studies
NR
No studies 12 · 34.3%Ungraded 0 · 0%Very low 2 · 5.7%Low 8 · 22.9%Moderate 9 · 25.7%High 4 · 11.4%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Bovine lung lavage surfactant extract compared with modified bovine minced lung surfactant extract in preterm infants for prevention of RDS
Population: Preterm infants for prevention of RDS
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Mortality prior to discharge (from any cause) Bovine lung lavage surfactant extract vs modified bovine minced lung surfactant extract | RR 1.24 [0.9, 1.71] | 2 studies · 1123 participants | Moderate Downgraded: imprecision |
Oxygen requirement at 36 weeks' postmenstrual age Bovine lung lavage surfactant extract vs modified bovine minced lung surfactant extract | RR 0.97 [0.79, 1.19] | 1 study · 749 participants | Moderate Downgraded: imprecision |
Death or oxygen requirement at 36 weeks' postmenstrual age Bovine lung lavage surfactant extract vs modified bovine minced lung surfactant extract | RR 1.02 [0.89, 1.17] | 2 studies · 1133 participants | High |
Pneumothorax. Bovine lung lavage surfactant extract vs modified bovine minced lung surfactant extract | RR 0.76 [0.43, 1.36] | 1 study · 749 participants | Moderate Downgraded: imprecision |
Pulmonary hemorrhage Bovine lung lavage surfactant extract vs modified bovine minced lung surfactant extract | RR 1.44 [0.88, 2.39] | 2 studies · 1123 participants | Low Downgraded: imprecision |
Severe IVH in infants receiving neuroimaging Bovine lung lavage surfactant extract vs modified bovine minced lung surfactant extract | RR 1.28 [0.89, 1.83] | 2 studies · 1087 participants | Low Downgraded: imprecision |
Neurodevelopmental outcome at approximately two years’ corrected age Bovine lung lavage surfactant extract vs modified bovine minced lung surfactant extract | no estimate extracted | NR | No studies |
Bovine lung lavage surfactant extract compared with modified bovine minced lung surfactant extract in preterm infants for treatment of RDS
Population: Preterm infants for treatment of RDS
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Mortality prior to discharge Bovine lung lavage surfactant extract vs modified bovine minced lung surfactant extract | RR 0.98 [0.79, 1.21] | 6 studies · 2231 participants | Moderate |
Oxygen requirement at 36 weeks' postmenstrual age (all infants) Bovine lung lavage surfactant extract vs modified bovine minced lung surfactant extract | RR 0.95 [0.82, 1.11] | 5 studies · 1564 participants | High |
Death or oxygen requirement at 36 weeks' postmenstrual age Bovine lung lavage surfactant extract vs modified bovine minced lung surfactant extract | RR 0.95 [0.86, 1.06] | 3 studies · 2009 participants | High |
Pneumothorax Bovine lung lavage surfactant extract vs modified bovine minced lung surfactant extract | RR 1.14 [0.85, 1.51] | 6 studies · 2224 participants | Low |
Pulmonary hemorrhage Bovine lung lavage surfactant extract vs modified bovine minced lung surfactant extract | RR 1.08 [0.74, 1.59] | 4 studies · 2138 participants | Moderate |
Severe IVH in infants receiving neuroimaging Bovine lung lavage surfactant extract vs modified bovine minced lung surfactant extract | RR 0.86 [0.68, 1.09] | 5 studies · 2040 participants | Moderate Downgraded: imprecision, inconsistency |
Neurodevelopmental outcome at approximately two years’ corrected age Bovine lung lavage surfactant extract vs modified bovine minced lung surfactant extract | no estimate extracted | NR | No studies |
Bovine lung lavage surfactant extract compared with porcine minced lung surfactant extract in preterm infants for treatment of RDS
Population: Preterm infants for treatment of RDS
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Mortality prior to discharge Bovine lung lavage surfactant extract vs porcine minced lung surfactant extract | RR 1.4 [0.51, 3.87] | 1 study · 54 participants | Low Downgraded: imprecision |
Oxygen requirement at 36 weeks' postmenstrual age Bovine lung lavage surfactant extract vs porcine minced lung surfactant extract | RR 0.75 [0.19, 3.04] | 1 study · 54 participants | Low Downgraded: imprecision |
Death or oxygen requirement at 36 weeks' postmenstrual age Bovine lung lavage surfactant extract vs porcine minced lung surfactant extract | no estimate extracted | NR | No studies |
Pneumothorax Bovine lung lavage surfactant extract vs porcine minced lung surfactant extract | no estimate extracted | NR | No studies |
Pulmonary hemorrhage Bovine lung lavage surfactant extract vs porcine minced lung surfactant extract | no estimate extracted | NR | No studies |
Severe intraventricular hemorrhage in infants who received neuroimaging Bovine lung lavage surfactant extract vs porcine minced lung surfactant extract | RR 0.83 [0.29, 2.41] | 1 study · 54 participants | Very low Downgraded: risk of bias, imprecision |
Neurodevelopmental outcome at approximately two years’ corrected age Bovine lung lavage surfactant extract vs porcine minced lung surfactant extract | no estimate extracted | NR | No studies |
Modified bovine minced lung surfactant extract compared with porcine minced lung surfactant extract in preterm infants for treatment of RDS
Population: Preterm infants for treatment of RDS
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Mortality prior to hospital discharge (from any cause) Modified bovine minced lung surfactant extract vs porcine minced lung surfactant extract | RR 1.44 [1.04, 2] | 9 studies · 901 participants | Moderate |
Oxygen requirement at 36 weeks' postmenstrual age Modified bovine minced lung surfactant extract vs porcine minced lung surfactant extract | RR 1.04 [0.83, 1.31] | 8 studies · 773 participants | Moderate Downgraded: risk of bias, imprecision |
Death or oxygen requirement at 36 weeks' postmenstrual age Modified bovine minced lung surfactant extract vs porcine minced lung surfactant extract | RR 1.3 [1.04, 1.64] | 3 studies · 448 participants | Moderate |
Pneumothorax Modified bovine minced lung surfactant extract vs porcine minced lung surfactant extract | RR 1.24 [0.71, 2.17] | 6 studies · 669 participants | Low Downgraded: risk of bias, imprecision |
Pulmonary hemorrhage Modified bovine minced lung surfactant extract vs porcine minced lung surfactant extract | RR 1.28 [0.81, 2.02] | 8 studies · 871 participants | Low Downgraded: risk of bias, imprecision |
Severe intraventricular hemorrhage in infants who received neuroimaging Modified bovine minced lung surfactant extract vs porcine minced lung surfactant extract | RR 1.28 [0.83, 1.97] | 7 studies · 705 participants | Very low Downgraded: risk of bias, imprecision |
Neurodevelopmental outcome at approximately two years’ corrected age Modified bovine minced lung surfactant extract vs porcine minced lung surfactant extract | no estimate extracted | NR | No studies |
Modified bovine minced lung surfactant extract compared with porcine lung lavage surfactant in preterm infants for treatment of RDS
Population: Preterm infants for treatment of RDS
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Mortality prior to hospital discharge (from any cause) Modified bovine minced lung surfactant extract vs porcine lung lavage surfactant | RR 1.1 [0.6, 1.99] | 1 study · 44 participants | Low Downgraded: imprecision |
Oxygen requirement at 36 weeks' postmenstrual age Modified bovine minced lung surfactant extract vs porcine lung lavage surfactant | no estimate extracted | NR | No studies |
Death or oxygen requirement at 36 weeks' postmenstrual age Modified bovine minced lung surfactant extract vs porcine lung lavage surfactant | no estimate extracted | NR | No studies |
Pneumothorax Modified bovine minced lung surfactant extract vs porcine lung lavage surfactant | RR 0.1 [0.01, 0.73] | 1 study · 44 participants | High |
Pulmonary hemorrhage Modified bovine minced lung surfactant extract vs porcine lung lavage surfactant | no estimate extracted | NR | No studies |
Severe intraventricular hemorrhage in infants who received neuroimaging Modified bovine minced lung surfactant extract vs porcine lung lavage surfactant | no estimate extracted | NR | No studies |
Neurodevelopmental outcome at approximately two years corrected age Modified bovine minced lung surfactant extract vs porcine lung lavage surfactant | no estimate extracted | NR | No studies |