Cochrane · systematic review · CD006405
Nasal high flow therapy for primary respiratory support in preterm infants
Hodgson, KA, Wilkinson, D, De Paoli, AG, et al. · Cochrane Database of Systematic Reviews · 2023 · Cochrane Library
NeonatalAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
14
current version
GRADE rated
14
No studies
0
Included studies
NR
No studies 0 · 0%Ungraded 0 · 0%Very low 1 · 7.1%Low 5 · 35.7%Moderate 8 · 57.1%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Nasal high flow compared to continuous positive airway pressure for primary respiratory support in preterm infants
Population: preterm infants requiring primary respiratory support
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Death (before hospital discharge) or BPD(supplemental oxygen/respiratory support at 36 weeks' postmenstrual age if born < 32 weeks' gestation, or 28 days if born ≥ 32 weeks' gestation) Nasal high flow vs continuous positive airway pressure | RR 1.09 [0.74, 1.6] | 7 studies · 1830 participants | Low Downgraded: risk of bias, imprecision |
Death (before hospital discharge) Nasal high flow vs continuous positive airway pressure | RR 0.78 [0.44, 1.39] | 9 studies · 2009 participants | Low Downgraded: risk of bias, imprecision |
BPD (supplemental oxygen/respiratory support at 36 weeks' postmenstrual age if born < 32 weeks' gestation, or 28 days if born ≥ 32 weeks' gestation) Nasal high flow vs continuous positive airway pressure | RR 1.14 [0.74, 1.76] | 8 studies · 1917 participants | Low Downgraded: risk of bias, imprecision |
Treatment failure within 72 hours of trial entry Nasal high flow vs continuous positive airway pressure | RR 1.7 [1.41, 2.06] | 9 studies · 2042 participants | Moderate Downgraded: risk of bias |
Mechanical ventilation within 72 hours of trial entry Nasal high flow vs continuous positive airway pressure | RR 1.04 [0.82, 1.31] | 9 studies · 2042 participants | Moderate Downgraded: risk of bias |
Pneumothorax (during assigned treatment) Nasal high flow vs continuous positive airway pressure | RR 0.66 [0.4, 1.08] | 10 studies · 2094 participants | Moderate Downgraded: risk of bias, imprecision |
Nasal trauma (during assigned treatment) Nasal high flow vs continuous positive airway pressure | RR 0.49 [0.36, 0.68] | 7 studies · 1595 participants | Moderate Downgraded: risk of bias |
Nasal high flow compared to nasal intermittent positive pressure ventilation for primary respiratory support in preterm infants
Population: preterm infants requiring primary respiratory support
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Death (before hospital discharge) or BPD (supplemental oxygen/respiratory support at 36 weeks' postmenstrual age if born < 32 weeks' gestation, or 28 days if born ≥ 32 weeks' gestation) Nasal high flow vs nasal intermittent positive pressure ventilation | RR 0.64 [0.3, 1.37] | 2 studies · 182 participants | Very low Downgraded: risk of bias, imprecision |
Death (before hospital discharge) Nasal high flow vs nasal intermittent positive pressure ventilation | RR 0.78 [0.36, 1.69] | 3 studies · 254 participants | Low Downgraded: risk of bias, imprecision |
BPD (supplemental oxygen/respiratory support at 36 weeks' postmenstrual age if born < 32 weeks' gestation, or 28 days if born ≥ 32 weeks' gestation) Nasal high flow vs nasal intermittent positive pressure ventilation | RR 1.19 [0.66, 2.12] | 3 studies · 271 participants | Low Downgraded: risk of bias, imprecision |
Treatment failure within 72 hours of trial entry Nasal high flow vs nasal intermittent positive pressure ventilation | RR 1.27 [0.9, 1.79] | 4 studies · 343 participants | Moderate Downgraded: risk of bias |
Mechanical ventilation within 72 hours of trial entry Nasal high flow vs nasal intermittent positive pressure ventilation | RR 0.91 [0.62, 1.33] | 4 studies · 343 participants | Moderate Downgraded: risk of bias |
Pneumothorax (during assigned treatment) Nasal high flow vs nasal intermittent positive pressure ventilation | RR 0.78 [0.4, 1.53] | 4 studies · 344 participants | Moderate Downgraded: risk of bias, imprecision |
Nasal trauma (during assigned treatment) Nasal high flow vs nasal intermittent positive pressure ventilation | RR 0.21 [0.09, 0.47] | 3 studies · 272 participants | Moderate Downgraded: risk of bias |