Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

111 questions · 118 findings · 48 reviews

No studies found 32 · 27.1%GRADE not reported 0 · 0%Very low 38 · 32.2%Low 36 · 30.5%Moderate 11 · 9.3%High 1 · 0.8%

Repeated single embryo transfer (mixed policies) vs multiple embryo transfer

Multiple pregnancy · transfer following in vitro fertilisation or intracytoplasmic sperm injection

Repeated single embryo transfer (mixed policies) probably leads to lower multiple pregnancy compared with multiple embryo transfer (moderate certainty).

1 finding from 1 review

Embryo culture with low oxygen concentration vs embryo culture with atmospheric oxygen concentration

Multiple pregnancy rate · Patients with multiple pregnancy rate

Embryo culture with low oxygen concentration showed no clear difference in multiple‐pregnancy rate compared with embryo culture with atmospheric oxygen concentration (low certainty).

1 finding from 1 review

Summary of findings table ‐ ICSI vs c‐IVF

Multiple pregnancy · : Couples with males presenting normal total sperm count and motility were included in this review.

Summary of findings table ‐ ICSI showed no clear difference in multiple Pregnancy compared with c‐IVF (moderate certainty).

1 finding from 1 review

LOD with and without medical ovulation vs medical ovulation induction alone

Multiple pregnancy · women with anovulatory PCOS and CC resistance

LOD with and without medical ovulation probably leads to lower multiple pregnancy compared with medical ovulation induction alone (moderate certainty).

1 finding from 1 review

ART with seminal plasma vs standard ART (IVF, ICSI, and frozen embryo transfer)

Multiple pregnancy · Women undergoing ART (IVF, ICSI, or frozen embryo transfer)

ART with seminal plasma showed no clear difference in multiple pregnancy compared with standard ART (IVF, ICSI, and frozen embryo transfer) (low certainty).

1 finding from 1 review