Cochrane · systematic review · CD013063
Endometrial injection of embryo culture supernatant for subfertile women in assisted reproduction
Siristatidis, CS, Sertedaki, E, Karageorgiou, V, et al. · Cochrane Database of Systematic Reviews · 2020 · Cochrane Library
Gynaecology and FertilityAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
14
current version
GRADE rated
8
No studies
6
Included studies
NR
No studies 6 · 42.9%Ungraded 0 · 0%Very low 7 · 50%Low 1 · 7.1%Moderate 0 · 0%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Embryo culture supernatant injection compared to no intervention for subfertile women in assisted reproduction
Population: Subfertile women undergoing assisted reproduction
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Live birth/ongoing pregnancy Embryo culture supernatant injection vs no intervention | OR 1.11 [0.73, 1.7] | 3 studies · 340 participants | Very low Downgraded: risk of bias, imprecision, inconsistency, publication bias |
Miscarriage Embryo culture supernatant injection vs no intervention | OR 0.89 [0.44, 1.78] | 4 studies · 430 participants | Very low Downgraded: risk of bias, imprecision, inconsistency, publication bias |
Clinical pregnancy Embryo culture supernatant injection vs no intervention | OR 1.13 [0.8, 1.61] | 5 studies · 526 participants | Very low Downgraded: risk of bias, imprecision, inconsistency, publication bias |
Ectopic pregnancy Embryo culture supernatant injection vs no intervention | OR 0.32 [0.01, 8.24] | 2 studies · 250 participants | Very low Downgraded: risk of bias, imprecision, inconsistency, publication bias |
Multiple pregnancy Embryo culture supernatant injection vs no intervention | OR 0.7 [0.26, 1.83] | 2 studies · 150 participants | Very low Downgraded: risk of bias, imprecision, inconsistency, publication bias |
Preterm delivery Embryo culture supernatant injection vs no intervention | OR 0.63 [0.17, 2.42] | 1 study · 90 participants | Very low Downgraded: risk of bias, imprecision, publication bias |
Foetal abnormalities Embryo culture supernatant injection vs no intervention | OR 3.1 [0.12, 79.23] | 1 study · 60 participants | Low Downgraded: imprecision |
Embryo culture supernatant compared to culture medium injection for subfertile women in assisted reproduction
Population: Subfertile women undergoing assisted reproduction
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Live birth/ongoing pregnancy Embryo culture supernatant vs culture medium injection | no estimate extracted | NR | No studies |
Miscarriage Embryo culture supernatant vs culture medium injection | no estimate extracted | NR | No studies |
Clinical pregnancy Embryo culture supernatant vs culture medium injection | OR 1.09 [0.48, 2.46] | 1 study · 96 participants | Very low Downgraded: risk of bias, imprecision, publication bias |
Ectopic pregnancy Embryo culture supernatant vs culture medium injection | no estimate extracted | NR | No studies |
Multiple pregnancy Embryo culture supernatant vs culture medium injection | no estimate extracted | NR | No studies |
Preterm delivery Embryo culture supernatant vs culture medium injection | no estimate extracted | NR | No studies |
Foetal abnormalities Embryo culture supernatant vs culture medium injection | no estimate extracted | NR | No studies |