Cochrane · systematic review · CD007618
Nonsteroidal anti‐inflammatory drugs for assisted reproductive technology
Nyachieo, A, Siristatidis, CS, Vaidakis, D · Cochrane Database of Systematic Reviews · 2019 · Cochrane Library
Gynaecology and FertilityAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
13
current version
GRADE rated
9
No studies
4
Included studies
NR
No studies 4 · 30.8%Ungraded 0 · 0%Very low 8 · 61.5%Low 1 · 7.7%Moderate 0 · 0%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Nonsteroidal anti‐inflammatory drugs compared to placebo/ no treatment for assisted reproductive technology
Population: assisted reproductive technology
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Ongoing pregnancy Nonsteroidal anti‐inflammatory drugs vs placebo/ no treatment | RR 1.06 [0.71, 1.59] | 4 studies · 1159 participants | Very low Downgraded: risk of bias |
Miscarriage Nonsteroidal anti‐inflammatory drugs vs placebo/ no treatment | RR 0.62 [0.33, 1.16] | 4 studies · 525 participants | Very low Downgraded: risk of bias |
Clinical pregnancy Nonsteroidal anti‐inflammatory drugs vs placebo/ no treatment | RR 1.23 [1, 1.52] | 7 studies · 1570 participants | Low Downgraded: risk of bias |
Ectopic Pregnancy Nonsteroidal anti‐inflammatory drugs vs placebo/ no treatment | RR 0.56 [0.05, 5.89] | 1 study · 72 participants | Very low Downgraded: risk of bias |
Multiple pregnancy Nonsteroidal anti‐inflammatory drugs vs placebo/ no treatment | RR 2 [0.18, 21.67] | 1 study · 180 participants | Very low Downgraded: risk of bias |
Side effects Nonsteroidal anti‐inflammatory drugs vs placebo/ no treatment | RR 1.39 [0.02, 119.35] | 3 studies · 418 participants | Very low Downgraded: risk of bias |
Piroxicam compared to indomethacin for assisted reproductive technology
Population: assisted reproductive technology
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Live birth Piroxicam vs indomethacin | no estimate extracted | NR | No studies |
Ongoing pregnancy Piroxicam vs indomethacin | RR 1.12 [0.63, 2] | 1 study · 170 participants | Very low Downgraded: risk of bias |
Miscarriage Piroxicam vs indomethacin | RR 1 [0.44, 2.28] | 1 study · 170 participants | Very low Downgraded: risk of bias |
Clinical pregnancy Piroxicam vs indomethacin | RR 1.07 [0.71, 1.63] | 1 study · 170 participants | Very low Downgraded: risk of bias |
Ectopic pregnancy Piroxicam vs indomethacin | no estimate extracted | NR | No studies |
Multiple pregnancy Piroxicam vs indomethacin | no estimate extracted | NR | No studies |
Side effects Piroxicam vs indomethacin | no estimate extracted | NR | No studies |