Systematic screening showed no clear difference in all‐cause mortality compared with no/opportunistic screening (low certainty).
Colchicine showed no clear difference in mortality (all‐cause) compared with any control treatment (moderate certainty).
Meta-analysis of randomised trials of vitamin D supplementation for Mortality (all cause) (Vitamin D2, general population): RR 1.04 (95% CI 0.97 to 1.11), not statistically significant. Umbrella review outcome-level evidence grade: No conclusion.
Vitamin D may leads to lower all‐cause mortality compared with placebo or no intervention (low certainty).
Meta-analysis of observational studies (higher vs lower 25(OH)D) for All cause mortality: HR 0.72 (95% CI 0.66 to 0.78), statistically significant. Umbrella review outcome-level evidence grade: No conclusion.
It is very uncertain whether macrolide+tetracycline changes all‐cause mortality 60 weeks (end of study) compared with macrolide (very low certainty).
Titrated oxygen therapy may leads to lower mortality (respiratory‐ related and all‐cause compared with high‐flow oxygen therapy (low certainty).
Triple therapy may leads to lower mortality (all‐cause) compared with LABA/LAMA combination (low certainty).
Summary of Findings Table ‐ Chronic non‐invasive ventilation showed no clear difference in all‐cause mortality compared with standard treatment following a severe exacerbation (low certainty).
Summary of Findings Table ‐ Chronic non‐invasive ventilation probably leads to lower all‐cause mortality compared with standard treatment (moderate certainty).
The review found no eligible studies for this question.
Antibiotics showed no clear difference in all‐cause mortality compared with placebo (low certainty).
Prophylactic corticosteroids showed no clear difference in all‐cause mortality (during the index hospital admission, or within… compared with placebo or no corticosteroids (low certainty).
It is very uncertain whether summary of findings table ‐ Pharmacological treatment changes all‐cause mortality ‐ short term compared with placebo (very low certainty).
It is very uncertain whether summary of findings table ‐ Psychological treatment changes all‐cause mortality ‐ short‐term compared with control (very low certainty).
Antibiotics showed no clear difference in all‐cause mortality WMD of compared with placebo (moderate certainty).
It is very uncertain whether ultrasound‐assisted catheter‐directed thrombolysis plus standard… changes all‐cause mortality (90‐day) compared with standard intravenous heparinisation (very low certainty).
It is very uncertain whether intervention changes all‐cause mortality (deaths) Â compared with usual care (very low certainty).