Cochrane · systematic review · CD011047
Colchicine for prevention of cardiovascular events
Hemkens, LG, Ewald, H, Gloy, VL, et al. · Cochrane Database of Systematic Reviews · 2016 · Cochrane Library
HeartAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
8
current version
GRADE rated
8
No studies
0
Included studies
NR
No studies 0 · 0%Ungraded 0 · 0%Very low 1 · 12.5%Low 4 · 50%Moderate 3 · 37.5%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Colchicine compared to any control treatment for prevention of cardiovascular events
Population: any patient population and people with high cardiovascular risk
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Mortality (all‐cause) Colchicine vs any control treatment | RR 0.94 [0.82, 1.09] | 30 studies · 4174 participants | Moderate Downgraded: imprecision |
Mortality (cardiovascular) Colchicine vs any control treatment | RR 0.34 [0.09, 1.21] | 7 studies · 1132 participants | Moderate Downgraded: imprecision |
Myocardial Infarction (total) Colchicine vs any control treatment | RR 0.2 [0.07, 0.57] | 2 studies · 652 participants | Moderate Downgraded: imprecision |
Adverse event (total) Colchicine vs any control treatment | RR 1.52 [0.93, 2.46] | 11 studies · 1313 participants | Very low Downgraded: risk of bias, imprecision, publication bias |
Adverse event (gastrointestinal) Colchicine vs any control treatment | RR 1.83 [1.03, 3.26] | 11 studies · 1258 participants | Low Downgraded: imprecision, inconsistency, publication bias |
Adverse event (serious) Colchicine vs any control treatment | no estimate extracted | 4 studies · 472 participants | Low Downgraded: publication bias |
Heart failure (total) Colchicine vs any control treatment | RR 0.62 [0.1, 3.88] | 3 studies · 426 participants | Low Downgraded: imprecision |
Stroke (total) Colchicine vs any control treatment | OR 0.38 [0.09, 1.7] | 3 studies · 874 participants | Low Downgraded: imprecision |