Cochrane · systematic review · CD013083
Catheter‐directed therapies for the treatment of high risk (massive) and intermediate risk (submassive) acute pulmonary embolism
Harvey, JJ, Huang, S, Uberoi, R · Cochrane Database of Systematic Reviews · 2022 · Cochrane Library
VascularAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
7
current version
GRADE rated
3
No studies
0
Included studies
NR
No studies 0 · 0%Ungraded 4 · 57.1%Very low 3 · 42.9%Low 0 · 0%Moderate 0 · 0%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Ultrasound‐assisted catheter‐directed thrombolysis plus standard intravenous heparinisation versus standard intravenous heparinisation
Population: people with intermediate‐risk (submassive) APE
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
All‐cause mortality(7‐day) Ultrasound‐assisted catheter‐directed thrombolysis plus standard intravenous heparinisation vs standard intravenous heparinisation | no estimate extracted | 1 study · 59 participants | Ungraded |
All‐cause mortality (90‐day) Ultrasound‐assisted catheter‐directed thrombolysis plus standard intravenous heparinisation vs standard intravenous heparinisation | OR 0.31 [0.01, 7.96] | 1 study · 59 participants | Very low Downgraded: risk of bias, imprecision |
Treatment‐associated major haemorrhage ( Ultrasound‐assisted catheter‐directed thrombolysis plus standard intravenous heparinisation vs standard intravenous heparinisation | no estimate extracted | 1 study · 59 participants | Ungraded |
Treatment‐associated minor haemorrhage ( Ultrasound‐assisted catheter‐directed thrombolysis plus standard intravenous heparinisation vs standard intravenous heparinisation | OR 3.11 [0.3, 31.79] | 1 study · 59 participants | Very low Downgraded: risk of bias, imprecision |
Recurrent APE requiring retreatment or change to a different APE treatment ( Ultrasound‐assisted catheter‐directed thrombolysis plus standard intravenous heparinisation vs standard intravenous heparinisation | no estimate extracted | 1 study · 59 participants | Ungraded |
Length of hospital stay (days) Ultrasound‐assisted catheter‐directed thrombolysis plus standard intravenous heparinisation vs standard intravenous heparinisation | no estimate extracted | 1 study · 59 participants | Very low Downgraded: risk of bias, imprecision |
Quality of life  Ultrasound‐assisted catheter‐directed thrombolysis plus standard intravenous heparinisation vs standard intravenous heparinisation | no estimate extracted | 1 study · 59 participants | Ungraded |