Cochrane · systematic review · CD007469
Vitamin D supplementation for prevention of cancer in adults
Bjelakovic, G, Gluud, LL, Nikolova, D, et al. · Cochrane Database of Systematic Reviews · 2014 · Cochrane Library
Metabolic and Endocrine DisordersAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
7
current version
GRADE rated
5
No studies
2
Included studies
NR
No studies 2 · 28.6%Ungraded 0 · 0%Very low 0 · 0%Low 3 · 42.9%Moderate 2 · 28.6%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Vitamin D versus placebo or no intervention for prevention of cancer in adults
Population: healthy participants or recruited among the general population; individuals diagnosed with a specific disease in a stable phase or with vitamin D deficiency
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Cancer occurrence Vitamin D vs placebo or no intervention | RR 1 [0.94, 1.06] | 18 studies · 50623 participants | Moderate Downgraded: risk of bias |
Cancer occurrence in trials using vitamin D₃ (cholecalciferol) Vitamin D vs placebo or no intervention | RR 1 [0.94, 1.06] | 14 studies · 49891 participants | Moderate Downgraded: risk of bias |
All‐cause mortality Vitamin D vs placebo or no intervention | RR 0.93 [0.88, 0.98] | 15 studies · 49866 participants | Low Downgraded: risk of bias, imprecision |
Cancer mortality in trials using vitamin D₃(cholecalciferol) Vitamin D vs placebo or no intervention | RR 0.88 [0.78, 0.98] | 4 studies · 44492 participants | Low Downgraded: risk of bias, imprecision |
Adverse events: nephrolithiasis in trials using vitamin D₃(cholecalciferol) combined with calcium Vitamin D vs placebo or no intervention | RR 1.17 [1.03, 1.34] | 3 studies · 42753 participants | Low Downgraded: risk of bias, imprecision |
Health‐related quality of life Vitamin D vs placebo or no intervention | no estimate extracted | NR | No studies |
Health economics Vitamin D vs placebo or no intervention | no estimate extracted | NR | No studies |