Findings

What do systematic reviews say?

7 questions · 7 findings · 6 reviews · Anaesthesia

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No studies found 0 · 0%GRADE not reported 1 · 14.3%Very low 3 · 42.9%Low 3 · 42.9%Moderate 0 · 0%High 0 · 0%

Protocol to increase global blood flow vs control

Mortality within the longest · surgical patients

Protocol to increase global blood flow showed no clear difference in mortality (Longest compared with control (low certainty).

1 finding from 1 review

Perioperative increase in global blood flow to explicit defined goals and outcomes following surgery 2012 · Cochrane Headline outcomes only
RR 0.89 [0.76, 1.05]
31 studies · 5292 participants
Low

Inhaled NO vs placebo or conventional therapy

Long‐term mortality · all infants and children with congenital heart disease having postoperative management of pulmonary hypertension

1 finding from 1 review

Inhaled nitric oxide for the postoperative management of pulmonary hypertension in infants and children with… 2014 · Cochrane Headline outcomes only
no estimate extracted
0 studies · 0 participants
GRADE not reported

Intervention not reported

Mortality within the longest · surgical patients with need for abdominal, caesarean section, orthopaedic or breast surgery

The intervention showed no clear difference in mortality within the longest (low certainty).

1 finding from 1 review

The effects of high perioperative inspiratory oxygen fraction for adult surgical patients 2015 · Cochrane Headline outcomes only
RR 1.12 [0.93, 1.36]
3 studies · 4758 participants
Low

Intervention not reported

Mortality within the longest · surgical patients with need for abdominal, caesarean section, orthopaedic or breast surgery

It is very uncertain whether the intervention changes mortality within the longest (very low certainty).

1 finding from 1 review

The effects of high perioperative inspiratory oxygen fraction for adult surgical patients 2015 · Cochrane Headline outcomes only
RR 1.07 [0.87, 1.33]
6 studies · 4525 participants
Very low

Continuation vs discontinuation of antiplatelet therapy

Mortality within the longest · adults undergoing non‐cardiac surgery

Continuation showed no clear difference in all‐cause mortality (at longest compared with discontinuation of antiplatelet therapy (low certainty).

1 finding from 1 review

Continuation versus discontinuation of antiplatelet therapy for bleeding and ischaemic events in adults undergoing… 2018 · Cochrane Headline outcomes only
RR 1.21 [0.34, 4.27]
5 studies · 659 participants
Low

Pulmonary artery perfusion with blood vs no perfusion during cardiopulmonary bypass

Mortality within the longest · adult surgical patients with the need for cardiopulmonary bypass‐dependent heart surgery

It is very uncertain whether pulmonary artery perfusion with blood changes all‐cause mortality within longest compared with no perfusion during cardiopulmonary bypass (very low certainty).

1 finding from 1 review

Pulmonary artery perfusion versus no perfusion during cardiopulmonary bypass for open heart surgery in adults 2018 · Cochrane Headline outcomes only
Peto OR 1.78 [0.43, 7.4]
4 studies · 210 participants
Very low

Perioperative restrictive fluid therapy vs goal‐directed fluid therapy

Mortality within the longest · adults receiving intravenous fluids while undergoing major non‐cardiac surgery

It is very uncertain whether perioperative restrictive fluid therapy changes all‐cause mortality (during longest compared with goal‐directed fluid therapy (very low certainty).

1 finding from 1 review

Perioperative restrictive versus goal‐directed fluid therapy for adults undergoing major non‐cardiac surgery 2019 · Cochrane Headline outcomes only
RD 0.03 [0, 0.06]
6 studies · 544 participants
Very low