Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

187 questions · 189 findings · 84 reviews

No studies found 16 · 8.5%GRADE not reported 7 · 3.7%Very low 44 · 23.3%Low 57 · 30.2%Moderate 47 · 24.9%High 18 · 9.5%

Surgical portosystemic shunts vs transjugular intrahepatic portosystemic shunt (TIPS)

All‐cause mortality at 30 days · people with cirrhotic portal hypertension

It is very uncertain whether surgical portosystemic shunts changes all‐cause mortality at 30 days compared with transjugular intrahepatic portosystemic shunt (TIPS) (very low certainty).

1 finding from 1 review

Surgical portosystemic shunts vs transjugular intrahepatic portosystemic shunt (TIPS)

All‐cause mortality at 5 years · people with cirrhotic portal hypertension

It is very uncertain whether surgical portosystemic shunts changes all‐cause mortality at 5 years compared with transjugular intrahepatic portosystemic shunt (TIPS) (very low certainty).

1 finding from 1 review

Intervention not reported

Overall mortality · alcohol consumers with high blood pressure

The intervention showed no clear difference in overall mortality (low certainty).

1 finding from 1 review

Protocol‐directed sedation management vs usual care

Hospital mortality · mechanically ventilated ICU adults and children requiring sedation management

Protocol‐directed sedation management showed no clear difference in hospital mortality compared with usual care (low certainty).

1 finding from 1 review

Mineralocorticoid receptor antagonists (MRAs) vs placebo or no treatment

All‐cause mortality · patients with chronic heart failure with preserved ejection fraction

Mineralocorticoid receptor antagonists (MRAs) showed no clear difference in all‐cause mortality compared with placebo or no treatment (moderate certainty).

1 finding from 1 review

CHRONIC: ACEi or ARB vs placebo

All‐cause mortality · Patients undergoing any type of surgery under general anaesthesia receiving ACEIs or ARBs perioperatively

It is very uncertain whether ACEIs or ARBs changes all‐cause mortality compared with placebo (very low certainty).

1 finding from 1 review

Intervention not reported

Mortality at longest · adult (≥ 18 years of age) patients receiving mechanical ventilation (via either an endotracheal tube or a tracheostomy) for acute…

It is very uncertain whether the intervention changes mortality at longest (very low certainty).

1 finding from 1 review

Lower blood pressure targets vs standard blood pressure targets

Cardiovascular mortality · cardiovascular disease with high blood pressure

Lower blood pressure targets showed no clear difference in cardiovascular mortality compared with standard blood pressure targets (moderate certainty).

1 finding from 1 review

Lung cancer screening with chest radiography +/‐ sputum cytology vs less intense screening

All‐cause mortality ‐ More frequent chest x‐ray screening versus less frequent screening · Patients with lung cancer

Lung cancer screening with chest radiography +/‐ sputum cytology showed no clear difference in all‐cause mortality ‐ More frequent chest x‐ray screening versus… compared with less intense screening (low certainty).

1 finding from 1 review

Lung cancer screening with chest radiography +/‐ sputum cytology vs less intense screening

Mortality: lung cancer · Patients with lung cancer

Lung cancer screening with chest radiography +/‐ sputum cytology showed no clear difference in lung cancer mortality ‐ More frequent chest x‐ray screening versus… compared with less intense screening (moderate certainty).

2 findings from 1 review

Lung cancer screening with chest radiography +/‐ sputum cytology vs less intense screening

All‐cause mortality ‐ Annual chest x‐ray plus 4‐monthly cytology versus annual x‐ray alone · Patients with lung cancer

Lung cancer screening with chest radiography +/‐ sputum cytology showed no clear difference in all‐cause mortality ‐ Annual chest x‐ray plus 4‐monthly cytology… compared with less intense screening (high certainty).

1 finding from 1 review

Periodontal treatment (scaling and root planing, alone or with antimicrobials) vs Alternative (less intensive) periodontal treatment, alone or with placebo

Perinatal mortality · Pregnant women considered to have periodontal disease (gingivitis or periodontitis) after dental examination

It is very uncertain whether periodontal treatment (scaling and root planing, alone or with… changes perinatal mortality (including fetal and neonatal deaths up to the… compared with alternative (less intensive) periodontal treatment, alone or with… (very low certainty).

1 finding from 1 review