Cochrane · systematic review · CD012670
Benzodiazepines for treatment of patients with delirium excluding those who are cared for in an intensive care unit
Li, Y, Ma, J, Jin, Y, et al. · Cochrane Database of Systematic Reviews · 2020 · Cochrane Library
Dementia and Cognitive ImprovementAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
15
current version
GRADE rated
9
No studies
6
Included studies
NR
No studies 6 · 40%Ungraded 0 · 0%Very low 6 · 40%Low 3 · 20%Moderate 0 · 0%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Benzodiazepines (lorazepam) vs placebo for treatment of delirium in non‐ICU settings
Population: end‐of‐life patients with advanced cancer and an episode of agitated delirium
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Length of delirium episode Benzodiazepines (lorazepam) vs placebo | no estimate extracted | NR | No studies |
Severity of delirium change in MDAS, high = worse Benzodiazepines (lorazepam) vs placebo | no estimate extracted | 1 study · 50 participants | Low Downgraded: imprecision |
Any adverse event Benzodiazepines (lorazepam) vs placebo | no estimate extracted | NR | No studies |
Length of hospital admission (days) Benzodiazepines (lorazepam) vs placebo | no estimate extracted | 1 study · 58 participants | Low Downgraded: imprecision |
Mortality from all causes Benzodiazepines (lorazepam) vs placebo | RR 0.33 [0.04, 3.02] | 1 study · 58 participants | Low Downgraded: imprecision |
Benzodiazepines (lorazepam) vs antipsychotics (chlorpromazine) for treatment of delirium in non‐ICU settings
Population: adult AIDS patients with delirium
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Length of delirium episode Benzodiazepines (lorazepam) vs antipsychotics (chlorpromazine) | no estimate extracted | NR | No studies |
Severity of delirium DRS, high = worse Benzodiazepines (lorazepam) vs antipsychotics (chlorpromazine) | no estimate extracted | 1 study · 19 participants | Very low Downgraded: risk of bias |
Any adverse event ESRS, higher = worse Benzodiazepines (lorazepam) vs antipsychotics (chlorpromazine) | no estimate extracted | 1 study · 19 participants | Very low Downgraded: risk of bias |
Length of hospital admission Benzodiazepines (lorazepam) vs antipsychotics (chlorpromazine) | no estimate extracted | NR | No studies |
Mortality from all causes Benzodiazepines (lorazepam) vs antipsychotics (chlorpromazine) | RR 0.87 [0.23, 3.26] | 1 study · 19 participants | Very low Downgraded: risk of bias |
Benzodiazepines (lorazepam) vs antipsychotics (haloperidol) for treatment of delirium in non‐ICU settings
Population: adult AIDS patients with delirium
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Length of delirium episode Benzodiazepines (lorazepam) vs antipsychotics (haloperidol) | no estimate extracted | NR | No studies |
Severity of delirium DRS, higher = worse Benzodiazepines (lorazepam) vs antipsychotics (haloperidol) | no estimate extracted | 1 study · 17 participants | Very low Downgraded: risk of bias |
Any adverse event ESRS, higher = worse Benzodiazepines (lorazepam) vs antipsychotics (haloperidol) | no estimate extracted | 1 study · 17 participants | Very low Downgraded: risk of bias |
Length of hospital admission Benzodiazepines (lorazepam) vs antipsychotics (haloperidol) | no estimate extracted | NR | No studies |
Mortality from all causes Benzodiazepines (lorazepam) vs antipsychotics (haloperidol) | RR 1.83 [0.34, 9.92] | 1 study · 17 participants | Very low Downgraded: risk of bias |