Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

559 questions · 576 findings · 177 reviews

No studies found 140 · 24.3%GRADE not reported 45 · 7.8%Very low 184 · 31.9%Low 131 · 22.7%Moderate 60 · 10.4%High 16 · 2.8%

Remote monitoring plus usual care vs usual care

Mortality (all‐cause) · patients with chronic obstructive pulmonary disease

It is very uncertain whether remote monitoring plus usual care changes mortality (all‐cause) compared with usual care (very low certainty).

1 finding from 1 review

IVIg vs placebo or no intervention

28‐Day all cause mortality (adult studies) · adult patients with sepsis, severe sepsis and septic shock

Polyclonal intravenous immunoglobulin (IVIG) probably leads to lower all‐cause mortality, adults, standard polyclonal IVIG compared with placebo or no intervention (moderate certainty).

5 findings from 1 review
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IVIg vs placebo or no intervention

All‐cause mortality, neonates, standard polyclonal IVIG · neonates with sepsis, severe sepsis and septic shock

Polyclonal intravenous immunoglobulin (IVIG) showed no clear difference in all‐cause mortality, neonates, standard polyclonal IVIG compared with placebo or no intervention (moderate certainty).

2 findings from 1 review

IVIg vs placebo or no intervention

All‐cause mortality, neonates, IgM‐enriched polyclonal IVIG · neonates with sepsis, severe sepsis and septic shock

Polyclonal intravenous immunoglobulin (IVIG) showed no clear difference in all‐cause mortality, neonates, IgM‐enriched polyclonal IVIG compared with placebo or no intervention (low certainty).

1 finding from 1 review

Vitamin D vs placebo or no intervention

Cancer mortality in trials using vitamin D3 (cholecalciferol) ( · healthy participants or recruited among the general population; individuals diagnosed with a specific disease in a stable phase or with…

Vitamin D may leads to lower cancer mortality in trials using vitamin D₃(cholecalciferol) compared with placebo or no intervention (low certainty).

1 finding from 1 review

Preoperative inspiratory muscle training vs usual care, non‐exercise intervention

Mortality In the early postoperative period (≤ 30 days) · adult participants undergoing cardiac and major abdominal surgery

It is very uncertain whether preoperative inspiratory muscle training changes all‐cause mortality within 30 days during postoperative period compared with usual care, non‐exercise intervention (very low certainty).

1 finding from 1 review

Dexrazoxane vs no cardioprotective intervention

Has died · children with cancer receiving anthracyclines

Dexrazoxane showed no clear difference in overall mortality (Reported as number of participants who died) compared with no cardioprotective intervention (low certainty).

1 finding from 1 review

Digital targeted client communication via mobile devices vs standard care or no intervention (pregnant and postpartum women with HIV)

Maternal mortality or morbidity · pregnant and postpartum women

It is very uncertain whether digital targeted client communication via mobile devices changes health status and well‐being – maternal mortality and morbidity compared with standard care or no intervention (pregnant and postpartum women) (very low certainty).

1 finding from 1 review