Cochrane · systematic review · CD011432

Interventions to increase tuberculosis case detection at primary healthcare or community‐level services

Mhimbira, FA, Cuevas, LE, Dacombe, R, et al. · Cochrane Database of Systematic Reviews · 2017 · Cochrane Library

Infectious DiseasesAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
22
current version
GRADE rated
10
No studies
3
Included studies
NR
No studies 3 · 13.6%Ungraded 9 · 40.9%Very low 5 · 22.7%Low 5 · 22.7%Moderate 0 · 0%High 0 · 0%

Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.

Questions and results

Tuberculosis outreach screening versus no intervention

Population: all age groups
6 questions
OutcomeEffectEvidenceStatus / GRADE
Tuberculosis cases detected (microbiologically confirmed)
Tuberculosis outreach screening vs no intervention
RR 1.24 [0.86, 1.79]4 studies · 163043 participantsLow
Downgraded: risk of bias, imprecision, inconsistency, indirectness
Default within first 2 months
Tuberculosis outreach screening vs no intervention
RR 0.67 [0.47, 0.96]849 participantsLow
Downgraded: risk of bias, imprecision, indirectness
Treatment success
Tuberculosis outreach screening vs no intervention
RR 1.07 [1, 1.15]849 participantsLow
Downgraded: risk of bias, imprecision
Treatment failure
Tuberculosis outreach screening vs no intervention
RR 1.57 [0.5, 4.92]849 participantsVery low
Downgraded: risk of bias, imprecision, indirectness
Tuberculosis mortality
Tuberculosis outreach screening vs no intervention
RR 0.99 [0.43, 2.25]849 participantsLow
Downgraded: risk of bias, imprecision, inconsistency, indirectness
Long‐term tuberculosis prevalence
Tuberculosis outreach screening vs no intervention
RR 1.14 [0.65, 2]556836 participantsVery low
Downgraded: risk of bias, imprecision, indirectness

Health promotion activities versus no intervention

Population: all age groups
4 questions
OutcomeEffectEvidenceStatus / GRADE
Long‐term tuberculosis prevalence (assessed at 4 years)
Health promotion activities vs no intervention
RR 1.31405788 participantsVery low
Downgraded: risk of bias, imprecision, inconsistency, indirectness
Treatment success
Health promotion activities vs no intervention
no estimate extractedNRNo studies
Tuberculosis mortality
Health promotion activities vs no intervention
no estimate extractedNRNo studies
Long‐term tuberculosis prevalence
Health promotion activities vs no intervention
no estimate extractedNRNo studies

Training interventions compared to no intervention

Population: all age groups
4 questions
OutcomeEffectEvidenceStatus / GRADE
Tuberculosis cases detected (microbiologically confirmed)
Training interventions vs no intervention
RR 1.68 [1.03, 2.72]1 study · 1999 participantsLow
Downgraded: risk of bias, imprecision, inconsistency, indirectness
Treatment success
Training interventions vs no intervention
no estimate extracted0 studies · 0 participantsUngraded
Tuberculosis mortality
Training interventions vs no intervention
no estimate extracted0 studies · 0 participantsUngraded
Long‐term tuberculosis prevalence
Training interventions vs no intervention
no estimate extracted0 studies · 0 participantsUngraded

Outreach tuberculosis screening versus health promotion

Population: adults
4 questions
OutcomeEffectEvidenceStatus / GRADE
Tuberculosis cases detected (microbiologically confirmed)
Outreach tuberculosis screening vs health promotion
RR 1.71 [1.27, 2.31]1 study · 110162 participantsVery low
Downgraded: risk of bias, imprecision, inconsistency, indirectness
Treatment success
Outreach tuberculosis screening vs health promotion
no estimate extracted0 studies · 0 participantsUngraded
Tuberculosis mortality
Outreach tuberculosis screening vs health promotion
no estimate extracted0 studies · 0 participantsUngraded
Long‐term tuberculosis prevalence
Outreach tuberculosis screening vs health promotion
no estimate extracted0 studies · 0 participantsUngraded

Outreach clinic versus house‐to‐house screening

Population: adults
4 questions
OutcomeEffectEvidenceStatus / GRADE
Tuberculosis cases detected (microbiologically confirmed)
Outreach clinic vs house‐to‐house screening
RR 1.48 [1.11, 1.97]1 study · 405819 participantsVery low
Downgraded: risk of bias, imprecision, inconsistency, indirectness
Treatment success
Outreach clinic vs house‐to‐house screening
no estimate extracted0 studies · 0 participantsUngraded
Tuberculosis mortality
Outreach clinic vs house‐to‐house screening
no estimate extracted0 studies · 0 participantsUngraded
Long‐term tuberculosis prevalence
Outreach clinic vs house‐to‐house screening
no estimate extracted0 studies · 0 participantsUngraded