IVIg vs placebo or no intervention: 28‐Day all cause mortality (adult studies)
Polyclonal intravenous immunoglobulin (IVIG) probably leads to lower all‐cause mortality, adults, standard polyclonal IVIG compared with placebo or no intervention (moderate certainty).
What each review found
Include earlier review versions| Finding | Effect | Studies | GRADE certainty |
|---|---|---|---|
Polyclonal intravenous immunoglobulin (IVIG) vs placebo or no intervention All‐cause mortality, adults, standard polyclonal IVIG · adult patients with sepsis, severe sepsis and septic shock Polyclonal intravenous immunoglobulin (IVIG) probably leads to lower all‐cause mortality, adults, standard polyclonal IVIG compared with placebo or no intervention (moderate certainty). Intravenous immunoglobulin for treating sepsis, severe sepsis and septic shock (2013) · Cochrane Headline outcomes only | RR 0.81 [0.7, 0.93] | 10 studies · 1430 participants | Moderate |
Polyclonal intravenous immunoglobulin (IVIG) vs placebo or no intervention All‐cause mortality, adults, IgM‐enriched polyclonal IVIG · adult patients with sepsis, severe sepsis and septic shock Polyclonal intravenous immunoglobulin (IVIG) probably leads to lower all‐cause mortality, adults, IgM‐enriched polyclonal IVIG compared with placebo or no intervention (moderate certainty). Intravenous immunoglobulin for treating sepsis, severe sepsis and septic shock (2013) · Cochrane Headline outcomes only | RR 0.66 [0.51, 0.85] | 7 studies · 528 participants | Moderate |
Polyclonal intravenous immunoglobulin (IVIG) vs placebo or no intervention Low risk of bias adult studies, by type of polyclonal IVIG, mortality all‐cause · adult patients with sepsis, severe sepsis and septic shock Polyclonal intravenous immunoglobulin (IVIG) showed no clear difference in low risk of bias adult studies, by type of polyclonal IVIG,… compared with placebo or no intervention (high certainty). Intravenous immunoglobulin for treating sepsis, severe sepsis and septic shock (2013) · Cochrane Headline outcomes only | RR 0.97 [0.81, 1.15] | 5 studies · 945 participants | High |
Polyclonal intravenous immunoglobulin (IVIG) vs placebo or no intervention Low risk of bias adult studies, mortality all‐cause ‐ standard IVIG · adult patients with sepsis, severe sepsis and septic shock Polyclonal intravenous immunoglobulin (IVIG) showed no clear difference in low risk of bias adult studies, mortality all‐cause ‐ standard IVIG compared with placebo or no intervention (high certainty). Intravenous immunoglobulin for treating sepsis, severe sepsis and septic shock (2013) · Cochrane Headline outcomes only | RR 1.02 [0.84, 1.24] | 3 studies · 683 participants | High |
Polyclonal intravenous immunoglobulin (IVIG) vs placebo or no intervention Low risk of bias adult studies, mortality all‐cause ‐ IgM‐enriched IVIG · adult patients with sepsis, severe sepsis and septic shock Polyclonal intravenous immunoglobulin (IVIG) showed no clear difference in low risk of bias adult studies, mortality all‐cause ‐ IgM‐enriched… compared with placebo or no intervention (moderate certainty). Intravenous immunoglobulin for treating sepsis, severe sepsis and septic shock (2013) · Cochrane Headline outcomes only | RR 0.82 [0.56, 1.19] | 2 studies · 262 participants | Moderate |
Findings are shown side by side, never pooled across reviews.
The reviews
| Review | Searched up to | Included studies | AMSTAR 2 |
|---|---|---|---|
| Intravenous immunoglobulin for treating sepsis, severe sepsis and septic shock 2013 · Cochrane Headline outcomes only | Not reported | list not extracted yet | Not assessed |
Studies behind the findings
None of these reviews ties its included studies to this outcome in the data here. Cochrane reviews and reviews with headline outcomes only do not list their studies yet.
How reviews are matched to this question
Reviews word the same question differently. Four decision models (TypeSafe's Jev, Liquid AI's d1-ultra, SubQ Snap and Baseten's Elephant) judged each wording of the population, intervention, comparator and outcome against the others; two wordings count as the same when at least three of them agree and none clearly disagrees, and findings count as this question only when all four elements match. Timing, setting and subgroup never split a question: they are shown on each finding.