Cochrane · systematic review · CD013683
Pharmacological interventions for preventing venous thromboembolism in people undergoing bariatric surgery
Amaral, FCF, Baptista-Silva, JCC, Nakano, LCU, et al. · Cochrane Database of Systematic Reviews · 2022 · Cochrane Library
VascularAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
28
current version
GRADE rated
24
No studies
4
Included studies
NR
No studies 4 · 14.3%Ungraded 0 · 0%Very low 11 · 39.3%Low 13 · 46.4%Moderate 0 · 0%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Higher‐dose heparin compared to standard‐dose heparin for preventing venous thromboembolism in people undergoing bariatric surgery
Population: people undergoing bariatric surgery
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
VTE Higher‐dose heparin vs standard‐dose heparin | RR 0.55 [0.05, 5.99] | 4 studies · 597 participants | Low Downgraded: risk of bias, imprecision |
Major bleeding Higher‐dose heparin vs standard‐dose heparin | RR 1.19 [0.48, 2.96] | 4 studies · 597 participants | Low Downgraded: risk of bias, imprecision |
All‐cause mortality Higher‐dose heparin vs standard‐dose heparin | no estimate extracted | 4 studies · 597 participants | Low Downgraded: imprecision |
VTE‐related mortality Higher‐dose heparin vs standard‐dose heparin | no estimate extracted | 4 studies · 597 participants | Low Downgraded: imprecision |
PE Higher‐dose heparin vs standard‐dose heparin | RR 0.37 [0.02, 8.92] | 2 studies · 310 participants | Very low Downgraded: risk of bias, imprecision |
DVT Higher‐dose heparin vs standard‐dose heparin | RR 1.1 [0.07, 17.4] | 4 studies · 597 participants | Very low Downgraded: risk of bias, imprecision |
Adverse events (thrombocytopenia) Higher‐dose heparin vs standard‐dose heparin | RR 1.1 [0.07, 17.4] | 2 studies · 310 participants | Very low Downgraded: risk of bias, imprecision |
Heparin compared to pentasaccharide for preventing venous thromboembolism in people undergoing bariatric surgery
Population: people undergoing bariatric surgery
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
VTE Heparin vs pentasaccharide | RR 0.83 [0.19, 3.61] | 1 study · 175 participants | Low Downgraded: risk of bias, imprecision |
Major bleeding Heparin vs pentasaccharide | RR 1.7 [0.42, 6.92] | 1 study · 198 participants | Very low Downgraded: risk of bias, imprecision |
All‐cause mortality Heparin vs pentasaccharide | no estimate extracted | 1 study · 198 participants | Very low Downgraded: risk of bias, imprecision |
VTE‐related mortality Heparin vs pentasaccharide | no estimate extracted | 1 study · 198 participants | Very low Downgraded: risk of bias, imprecision |
PE Heparin vs pentasaccharide | no estimate extracted | 1 study · 198 participants | Very low Downgraded: risk of bias, imprecision |
DVT Heparin vs pentasaccharide | RR 0.83 [0.19, 3.61] | 1 study · 175 participants | Low Downgraded: risk of bias, imprecision |
Adverse events (thrombocytopenia) Heparin vs pentasaccharide | RR 0.34 [0.01, 8.25] | 1 study · 198 participants | Very low Downgraded: risk of bias, imprecision |
Heparin started before compared to after the surgical procedure for preventing venous thromboembolism in people undergoing bariatric surgery
Population: people undergoing bariatric surgery
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
VTE Heparin started before vs after the surgical procedure | RR 0.11 [0.01, 2.01] | 1 study · 100 participants | Low Downgraded: risk of bias, imprecision |
Major bleeding Heparin started before vs after the surgical procedure | RR 3 [0.13, 71.92] | 1 study · 100 participants | Very low Downgraded: risk of bias, imprecision |
All‐cause mortality Heparin started before vs after the surgical procedure | no estimate extracted | 1 study · 100 participants | Very low Downgraded: risk of bias, imprecision |
VTE‐related mortality Heparin started before vs after the surgical procedure | no estimate extracted | 1 study · 100 participants | Very low Downgraded: risk of bias, imprecision |
PE Heparin started before vs after the surgical procedure | no estimate extracted | NR | No studies |
DVT Heparin started before vs after the surgical procedure | RR 0.11 [0.01, 2.01] | 1 study · 100 participants | Low Downgraded: risk of bias, imprecision |
Adverse events (thrombocytopenia) Heparin started before vs after the surgical procedure | no estimate extracted | NR | No studies |
Combined mechanical and pharmacological prophylaxis compared to mechanical prophylaxis alone for preventing venous thromboembolism in people undergoing bariatric surgery
Population: people undergoing bariatric surgery
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
VTE Combined mechanical and pharmacological prophylaxis vs mechanical prophylaxis alone | RR 0.05 [0, 0.89] | 1 study · 150 participants | Low Downgraded: imprecision |
Major bleeding Combined mechanical and pharmacological prophylaxis vs mechanical prophylaxis alone | no estimate extracted | 1 study · 150 participants | Low Downgraded: imprecision |
All‐cause mortality Combined mechanical and pharmacological prophylaxis vs mechanical prophylaxis alone | no estimate extracted | 1 study · 150 participants | Low Downgraded: imprecision |
VTE‐related mortality Combined mechanical and pharmacological prophylaxis vs mechanical prophylaxis alone | no estimate extracted | 1 study · 150 participants | Low Downgraded: imprecision |
PE Combined mechanical and pharmacological prophylaxis vs mechanical prophylaxis alone | no estimate extracted | NR | No studies |
DVT Combined mechanical and pharmacological prophylaxis vs mechanical prophylaxis alone | RR 0.05 [0, 0.89] | 1 study · 150 participants | Low Downgraded: imprecision |
Adverse events Combined mechanical and pharmacological prophylaxis vs mechanical prophylaxis alone | no estimate extracted | NR | No studies |