Findings

What do systematic reviews say?

18 questions · 18 findings · 12 reviews

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No studies found 3 · 16.7%GRADE not reported 0 · 0%Very low 7 · 38.9%Low 6 · 33.3%Moderate 2 · 11.1%High 0 · 0%

IVF vs unstimulated IUI

Miscarriage · women with unexplained subfertility

It is very uncertain whether IVF changes miscarriage rate per woman randomised compared with unstimulated IUI (very low certainty).

1 finding from 1 review

In vitro fertilisation for unexplained subfertility 2023 · Cochrane Headline outcomes only
OR 1.72 [0.14, 21.25]
1 study · 43 participants
Very low

IVF vs IUI + ovarian stimulation with gonadotropins or CC

Miscarriage · women with unexplained subfertility

It is very uncertain whether IVF changes miscarriage rate per woman randomised compared with IUI + ovarian stimulation with gonadotropins or CC (very low certainty).

1 finding from 1 review

In vitro fertilisation for unexplained subfertility 2023 · Cochrane Headline outcomes only
OR 0.31 [0.03, 3.04]
1 study · 207 participants
Very low

IVF vs expectant management

Miscarriage · women with unexplained subfertility

The review found no eligible studies for this question.

1 finding from 1 review

In vitro fertilisation for unexplained subfertility 2023 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Day 3 vs Day 2 embryo transfer following IVF or ICSI

Miscarriage · Women undergoing in vitro fertilisation or intracytoplasmic sperm injection

Day 3 showed no clear difference in miscarriage rate per woman compared with day 2 embryo transfer following IVF or ICSI (moderate certainty).

1 finding from 1 review

Day three versus day two embryo transfer following in vitro fertilization or intracytoplasmic sperm injection 2016 · Cochrane Headline outcomes only
RR 1.16 [0.84, 1.6]
9 studies · 2153 participants
Moderate

Laparoscopic proximal tubal occlusion vs laparoscopic salpingectomy

Miscarriage · tubal disease in women due to undergo in vitro fertilisation

The review found no eligible studies for this question.

1 finding from 1 review

Surgical treatment for tubal disease in women due to undergo in vitro fertilisation 2020 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Transvaginal aspiration of hydrosalpingeal fluid vs laparoscopic salpingectomy

Miscarriage · tubal disease in women due to undergo in vitro fertilisation

It is very uncertain whether transvaginal aspiration of hydrosalpingeal fluid changes miscarriage rate compared with laparoscopic salpingectomy (very low certainty).

1 finding from 1 review

Surgical treatment for tubal disease in women due to undergo in vitro fertilisation 2020 · Cochrane Headline outcomes only
Peto OR 1 [0.2, 5.08]
1 study · 160 participants
Very low

Tubal surgery vs no surgery

Miscarriage · tubal disease in women due to undergo in vitro fertilisation

The review found no eligible studies for this question.

1 finding from 1 review

Surgical treatment for tubal disease in women due to undergo in vitro fertilisation 2020 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Repeated single embryo transfer (mixed policies) vs multiple embryo transfer

Miscarriage · transfer following in vitro fertilisation or intracytoplasmic sperm injection

Repeated single embryo transfer (mixed policies) showed no clear difference in miscarriage rate compared with multiple embryo transfer (low certainty).

1 finding from 1 review

Number of embryos for transfer following in vitro fertilisation or intra‐cytoplasmic sperm injection 2020 · Cochrane Headline outcomes only
odds ratio 2.14 [0.93, 4.95]
2 studies · 282 participants
Low

Single vs multiple embryo transfer

Miscarriage · transfer following in vitro fertilisation or intracytoplasmic sperm injection

Single showed no clear difference in miscarriage rate compared with multiple embryo transfer (low certainty).

1 finding from 1 review

Number of embryos for transfer following in vitro fertilisation or intra‐cytoplasmic sperm injection 2020 · Cochrane Headline outcomes only
odds ratio 0.96 [0.66, 1.42]
7 studies · 1560 participants
Low

Long‐term GnRH agonist therapy vs no additional therapy

Miscarriage · patients with endometriosis prior to standard IVF/ICSI

It is very uncertain whether long‐term GnRH agonist therapy changes miscarriage rate compared with no additional therapy (very low certainty).

1 finding from 1 review

Long‐term GnRH agonist therapy before in vitro fertilisation (IVF) for improving fertility outcomes in women with… 2019 · Cochrane Headline outcomes only
Peto OR 0.45 [0.1, 2]
2 studies · 208 participants
Very low

Recombinant luteinizing hormone (rLH) combined with recombinant follicle‐stimulating hormone (rFSH) vs rFSH alone

Miscarriage · Women undergoing ovarian stimulation with gonadotrophins in IVF and ICSI procedures

Recombinant luteinizing hormone (rLH) combined with recombinant… showed no clear difference in miscarriage rate compared with rFSH alone (moderate certainty).

1 finding from 1 review

Recombinant luteinizing hormone (rLH) and recombinant follicle stimulating hormone (rFSH) for ovarian stimulation in… 2017 · Cochrane Headline outcomes only
OR 0.93 [0.63, 1.36]
13 studies · 1711 participants
Moderate

Glucocorticoid supplementation vs placebo

Miscarriage · Women undergoing IVF/ICSI cycles

It is very uncertain whether glucocorticoid supplementation changes miscarriage rate per woman compared with placebo (very low certainty).

1 finding from 1 review

Glucocorticoid supplementation during ovarian stimulation for IVF or ICSI 2017 · Cochrane Headline outcomes only
OR 1 [0.05, 18.57]
1 study · 20 participants
Very low

RhCG vs uhCG

Miscarriage · patients with final oocyte maturation triggering in IVF and ICSI cycles

RhCG showed no clear difference in miscarriage rate per woman compared with uhCG (low certainty).

1 finding from 1 review

Recombinant versus urinary human chorionic gonadotrophin for final oocyte maturation triggering in IVF and ICSI cycles 2016 · Cochrane Headline outcomes only
OR 0.72 [0.41, 1.25]
9 studies · 1347 participants
Low

RhLH vs uhCG

Miscarriage · patients with final oocyte maturation triggering in IVF and ICSI cycles

It is very uncertain whether rhLH changes miscarriage rate per woman compared with uhCG (very low certainty).

1 finding from 1 review

Recombinant versus urinary human chorionic gonadotrophin for final oocyte maturation triggering in IVF and ICSI cycles 2016 · Cochrane Headline outcomes only
OR 0.95 [0.38, 2.4]
2 studies · 280 participants
Very low

Brief co‐incubation vs standard insemination

Miscarriage · patients with in vitro fertilization techniques

Brief co‐incubation showed no clear difference in miscarriage rate per randomized woman compared with standard insemination (low certainty).

1 finding from 1 review

Brief co‐incubation of sperm and oocytes for in vitro fertilization techniques 2013 · Cochrane Headline outcomes only
OR 1.98 [0.35, 11.09]
1 study · 167 participants
Low

Metformin vs placebo or no treatment

Miscarriage · women with polycystic ovary syndrome

Metformin showed no clear difference in miscarriage rate per woman compared with placebo or no treatment (low certainty).

1 finding from 1 review · compare the 2 reviews

Metformin treatment before and during IVF or ICSI in women with polycystic ovary syndrome 2020 · Cochrane Headline outcomes only
RR 0.86 [0.56, 1.32]
8 studies · 821 participants
Low

Low‐dose aspirin vs placebo or no treatment

Miscarriage · women with subfertility

Low‐dose aspirin showed no clear difference in miscarriage rate per woman compared with placebo or no treatment (low certainty).

1 finding from 1 review

Aspirin for in vitro fertilisation 2016 · Cochrane Headline outcomes only
RR 1.1 [0.68, 1.77]
5 studies · 1497 participants
Low

Assisted hatching vs no assisted hatching

Miscarriage · women undergoing assisted reproduction

It is very uncertain whether assisted hatching changes miscarriage rate per woman randomised compared with no assisted hatching (very low certainty).

1 finding from 1 review

Assisted hatching on assisted conception (in vitro fertilisation (IVF) and intracytoplasmic sperm injection (ICSI)) 2021 · Cochrane Headline outcomes only
OR 1.13 [0.82, 1.56]
17 studies · 2810 participants
Very low