Cochrane · systematic review · CD005070
Recombinant luteinizing hormone (rLH) and recombinant follicle stimulating hormone (rFSH) for ovarian stimulation in IVF/ICSI cycles
Mochtar, MH, Danhof, NA, Ayeleke, RO, et al. · Cochrane Database of Systematic Reviews · 2017 · Cochrane Library
Gynaecology and FertilityAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
6
current version
GRADE rated
6
No studies
0
Included studies
NR
No studies 0 · 0%Ungraded 0 · 0%Very low 2 · 33.3%Low 2 · 33.3%Moderate 2 · 33.3%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Recombinant luteinizing hormone (rLH) combined with recombinant follicle‐stimulating hormone (rFSH) versus rFSH alone
Population: women undergoing ovarian stimulation in IVF or ICSI treatment cycles
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Live birth rate Recombinant luteinizing hormone (rLH) combined with recombinant follicle‐stimulating hormone (rFSH) vs rFSH alone | OR 1.32 [0.85, 2.06] | 4 studies · 499 participants | Very low Downgraded: risk of bias, imprecision |
OHSS incidence Recombinant luteinizing hormone (rLH) combined with recombinant follicle‐stimulating hormone (rFSH) vs rFSH alone | OR 0.38 [0.14, 1.01] | 6 studies · 2178 participants | Low Downgraded: imprecision |
Ongoing pregnancy rate Recombinant luteinizing hormone (rLH) combined with recombinant follicle‐stimulating hormone (rFSH) vs rFSH alone | OR 1.2 [1.01, 1.42] | 19 studies · 3129 participants | Moderate Downgraded: risk of bias |
Miscarriage rate Recombinant luteinizing hormone (rLH) combined with recombinant follicle‐stimulating hormone (rFSH) vs rFSH alone | OR 0.93 [0.63, 1.36] | 13 studies · 1711 participants | Moderate Downgraded: imprecision |
Cancellation rate for low response Recombinant luteinizing hormone (rLH) combined with recombinant follicle‐stimulating hormone (rFSH) vs rFSH alone | OR 0.77 [0.54, 1.1] | 11 studies · 2251 participants | Low Downgraded: risk of bias, imprecision |
Cancellation rate for imminent OHSS Recombinant luteinizing hormone (rLH) combined with recombinant follicle‐stimulating hormone (rFSH) vs rFSH alone | OR 0.6 [0.4, 0.89] | 8 studies · 2976 participants | Very low Downgraded: risk of bias |