Cochrane · systematic review · CD006105
Metformin treatment before and during IVF or ICSI in women with polycystic ovary syndrome
Tso, LO, Costello, MF, Albuquerque, LET, et al. · Cochrane Database of Systematic Reviews · 2020 · Cochrane Library
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
7
current version
GRADE rated
7
No studies
0
Included studies
NR
No studies 0 · 0%Ungraded 0 · 0%Very low 1 · 14.3%Low 6 · 85.7%Moderate 0 · 0%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Show all 2 versionsMetformin compared to placebo or no treatment in women with polycystic ovary syndrome
Population: women with polycystic ovary syndrome
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Live birth rate per woman ‐ long protocol GnRH‐agonist Metformin vs placebo or no treatment | RR 1.3 [0.94, 1.79] | 6 studies · 651 participants | Low Downgraded: risk of bias, imprecision, inconsistency |
Live birth rate per woman ‐ short protocol GnRH‐antagonist Metformin vs placebo or no treatment | RR 0.48 [0.29, 0.79] | 1 study · 153 participants | Low Downgraded: imprecision |
Incidence of OHSS per woman Metformin vs placebo or no treatment | RR 0.46 [0.29, 0.72] | 11 studies · 1091 participants | Low Downgraded: risk of bias, imprecision |
Clinical pregnancy rate per woman ‐ long protocol GnRH‐agonist Metformin vs placebo or no treatment | RR 1.32 [1.08, 1.63] | 10 studies · 915 participants | Low Downgraded: risk of bias, imprecision, inconsistency |
Clinical pregnancy rate per woman ‐ short protocol GnRH‐antagonist Metformin vs placebo or no treatment | RR 1.38 [0.21, 9.14] | 2 studies · 177 participants | Very low Downgraded: risk of bias, imprecision, inconsistency |
Miscarriage rate per woman Metformin vs placebo or no treatment | RR 0.86 [0.56, 1.32] | 8 studies · 821 participants | Low Downgraded: risk of bias, imprecision |
Side effects per woman Metformin vs placebo or no treatment | RR 3.35 [2.34, 4.79] | 8 studies · 748 participants | Low Downgraded: risk of bias, imprecision |