Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

30 questions · 31 findings · 21 reviews

No studies found 4 · 12.9%GRADE not reported 0 · 0%Very low 9 · 29%Low 12 · 38.7%Moderate 6 · 19.4%High 0 · 0%

IVF vs unstimulated IUI

Miscarriage · women with unexplained subfertility

It is very uncertain whether IVF changes miscarriage rate per woman randomised compared with unstimulated IUI (very low certainty).

1 finding from 1 review

ART with seminal plasma vs standard ART (IVF, ICSI, and frozen embryo transfer)

Miscarriage · Women undergoing ART (IVF, ICSI, or frozen embryo transfer)

ART with seminal plasma showed no clear difference in miscarriage compared with standard ART (IVF, ICSI, and frozen embryo transfer) (low certainty).

1 finding from 1 review

Day 3 vs Day 2 embryo transfer following IVF or ICSI

Miscarriage · Women undergoing in vitro fertilisation or intracytoplasmic sperm injection

Day 3 showed no clear difference in miscarriage rate per woman compared with day 2 embryo transfer following IVF or ICSI (moderate certainty).

1 finding from 1 review

Summary of findings table ‐ ICSI vs c‐IVF

Miscarriage · : Couples with males presenting normal total sperm count and motility were included in this review.

Summary of findings table ‐ ICSI showed no clear difference in miscarriage compared with c‐IVF (moderate certainty).

1 finding from 1 review

Transvaginal aspiration of hydrosalpingeal fluid vs laparoscopic salpingectomy

Miscarriage · tubal disease in women due to undergo in vitro fertilisation

It is very uncertain whether transvaginal aspiration of hydrosalpingeal fluid changes miscarriage rate compared with laparoscopic salpingectomy (very low certainty).

1 finding from 1 review

Repeated single embryo transfer (mixed policies) vs multiple embryo transfer

Miscarriage · transfer following in vitro fertilisation or intracytoplasmic sperm injection

Repeated single embryo transfer (mixed policies) showed no clear difference in miscarriage rate compared with multiple embryo transfer (low certainty).

1 finding from 1 review

Long‐term GnRH agonist therapy vs no additional therapy

Miscarriage · patients with endometriosis prior to standard IVF/ICSI

It is very uncertain whether long‐term GnRH agonist therapy changes miscarriage rate compared with no additional therapy (very low certainty).

1 finding from 1 review

Recombinant luteinizing hormone (rLH) combined with recombinant follicle‐stimulating hormone (rFSH) vs rFSH alone

Miscarriage · Women undergoing ovarian stimulation with gonadotrophins in IVF and ICSI procedures

Recombinant luteinizing hormone (rLH) combined with recombinant… showed no clear difference in miscarriage rate compared with rFSH alone (moderate certainty).

1 finding from 1 review