Cochrane · systematic review · CD005291
Preimplantation genetic testing for aneuploidies (abnormal number of chromosomes) in in vitro fertilisation
Cornelisse, S, Zagers, M, Kostova, E, et al. · Cochrane Database of Systematic Reviews · 2020 · Cochrane Library
Gynaecology and FertilityAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
12
current version
GRADE rated
9
No studies
3
Included studies
NR
No studies 3 · 25%Ungraded 0 · 0%Very low 0 · 0%Low 6 · 50%Moderate 3 · 25%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Preimplantation genetic testing for aneuploidies with the use genome‐wide analyses in in vitro fertilisation
Population: couples with an in vitro fertilisation indication
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Outcomes per woman | no estimate extracted | NR | No studies |
Cumulative live birth | OR 1.05 [0.66, 1.66] | 1 study · 396 participants | Low Downgraded: imprecision |
Live birth rate after the first embryo transfer | OR 1.1 [0.68, 1.79] | 1 study · 396 participants | Low Downgraded: imprecision |
Miscarriage | OR 0.45 [0.23, 0.88] | 1 study · 396 participants | Low Downgraded: imprecision |
Ongoing pregnancy | no estimate extracted | NR | No studies |
Clinical pregnancy | OR 0.77 [0.5, 1.16] | 1 study · 396 participants | Low Downgraded: imprecision |
Preimplantation genetic testing for aneuploidies with the use of fluorescence in situ hybridisation (FISH) for the genetic analysis in in vitro fertilisation
Population: couples with an in vitro fertilisation indication
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Outcomes per woman | no estimate extracted | NR | No studies |
Cumulative live birth | OR 0.59 [0.35, 1.01] | 1 study · 408 participants | Low Downgraded: imprecision |
Live birth rate after the first embryo transfer | OR 0.62 [0.43, 0.91] | 10 studies · 1680 participants | Moderate Downgraded: inconsistency |
Miscarriage | OR 1.03 [0.75, 1.41] | 10 studies · 1680 participants | Moderate Downgraded: imprecision |
Ongoing pregnancy | OR 0.68 [0.51, 0.9] | 5 studies · 1121 participants | Low Downgraded: imprecision, inconsistency |
Clinical pregnancy | OR 0.56 [0.42, 0.73] | 5 studies · 1131 participants | Moderate Downgraded: imprecision |