Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

54 questions · 55 findings · 30 reviews · Schizophrenia

No studies found 2 · 3.6%GRADE not reported 1 · 1.8%Very low 38 · 69.1%Low 8 · 14.5%Moderate 4 · 7.3%High 2 · 3.6%

Group C cognitive behavioural therapy: cognitive behavioural therapy + placebo vs placebo or supportive treatment

Satisfaction with treatment: leaving the study early Endpoint data (events) · people in the prodromal stage of psychosis

It is very uncertain whether group C cognitive behavioural therapy: cognitive behavioural therapy… changes satisfaction with treatment: leaving the study early Endpoint data… compared with supportive therapy + placebo (very low certainty).

1 finding from 1 review

Zuclopenthixol dihydrochloride vs placebo

Leaving the study early · patients with schizophrenia

It is very uncertain whether zuclopenthixol dihydrochloride changes leaving the study early (any reason) compared with placebo (very low certainty).

2 findings from 2 reviews · compare the 2 reviews

HALOPERIDOL vs placebo

Leaving the study early · patients with schizophrenia

HALOPERIDOL showed no clear difference in leaving the study early compared with PLACEBO (moderate certainty).

1 finding from 1 review

ASENAPINE vs placebo

Leaving the study early · adults with schizophrenia

It is very uncertain whether ASENAPINE changes leaving the study early ‐ any reason compared with PLACEBO (very low certainty).

1 finding from 1 review

ENZYME INHIBITOR ‐ VMAT2‐INHIBITOR (valbenazine) vs placebo

Leaving the study early · 18 to 85 year‐old patients with schizophrenia, schizoaffective disorder, mood disorder, or gastrointestinal disorder +…

It is very uncertain whether ENZYME INHIBITOR ‐ VMAT2‐INHIBITOR (valbenazine) changes leaving the study early compared with PLACEBO (very low certainty).

1 finding from 1 review

Sildenafil vs placebo

Leaving the study early · patients with sexual dysfunction due to antipsychotic drug therapy

It is very uncertain whether ADJUNCTIVE TREATMENT ‐ SPECIFIC: SILDENAFIL changes leaving the study early compared with PLACEBO (very low certainty).

1 finding from 1 review

RISPERIDONE vs placebo

Behaviour: Leaving the study early (short‐term) · patients with schizophrenia

RISPERIDONE may leads to lower leaving the study early ‐ short term (up to 12 weeks) ‐ any reason compared with PLACEBO (low certainty).

1 finding from 1 review

TRIFLUOPERAZINE vs placebo

Leaving the study early · patients with schizophrenia

It is very uncertain whether TRIFLUOPERAZINE changes leaving the study early ‐ any reason ‐ medium term Number of… compared with PLACEBO (very low certainty).

1 finding from 1 review