Cochrane · systematic review · CD000284
Chlorpromazine versus placebo for schizophrenia
Adams, CE, Awad, GA, Rathbone, J, et al. · Cochrane Database of Systematic Reviews · 2014 · Cochrane Library
SchizophreniaAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
7
current version
GRADE rated
5
No studies
2
Included studies
NR
No studies 2 · 28.6%Ungraded 0 · 0%Very low 4 · 57.1%Low 1 · 14.3%Moderate 0 · 0%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
CHLORPROMAZINE versus PLACEBO for schizophrenia
Population: patients with schizophrenia
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Death CHLORPROMAZINE vs PLACEBO | no estimate extracted | 1 study · 14 participants | Very low Downgraded: risk of bias, imprecision |
Relapse CHLORPROMAZINE vs PLACEBO | RR 0.65 [0.47, 0.9] | 3 studies · 512 participants | Very low Downgraded: risk of bias, inconsistency |
Global state: no overall improvement (psychiatrist ‐ rated) CHLORPROMAZINE vs PLACEBO | RR 0.71 [0.58, 0.9] | 14 studies · 1164 participants | Very low Downgraded: risk of bias, imprecision, inconsistency, publication bias |
Leaving the study early CHLORPROMAZINE vs PLACEBO | RR 0.64 [0.53, 0.78] | 27 studies · 1831 participants | Low Downgraded: risk of bias |
Satisfaction with treatment ‐ not reported CHLORPROMAZINE vs PLACEBO | no estimate extracted | NR | No studies |
Behaviour: deteriorated/ disturbed/un‐cooperative CHLORPROMAZINE vs PLACEBO | RR 0.49 [0.24, 1] | 8 studies · 1040 participants | Very low Downgraded: risk of bias, inconsistency |
Cost of care ‐ not reported CHLORPROMAZINE vs PLACEBO | no estimate extracted | NR | No studies |