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What do systematic reviews say?

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Evidence found and GRADE certainty

28 questions · 28 findings · 15 reviews · Schizophrenia

No studies found 5 · 17.9%GRADE not reported 12 · 42.9%Very low 6 · 21.4%Low 2 · 7.1%Moderate 3 · 10.7%High 0 · 0%

Modafinil vs placebo

Global state: clinically important change in global state · schizophrenia or related disorders

It is very uncertain whether modafinil changes global state: clinically important change in global state compared with placebo (very low certainty).

1 finding from 1 review

Intervention not reported

Global state: clinically important change in global state · people with primary delusional infestation
1 finding from 1 review

Intervention not reported

Global state: clinically important change in global state · patients with schizophrenia
1 finding from 1 review

ASENAPINE vs placebo

Global state: No clinically important change (as defined by the original studies) · adults with schizophrenia

ASENAPINE may leads to lower global state: No clinically important change CGI‐I compared with PLACEBO (low certainty).

1 finding from 1 review

Haloperidol discontinuation vs haloperidol continuation

Global state: 2. Clinically important change (no improvement) ‐ long term · schizophrenia

It is very uncertain whether haloperidol discontinuation changes global state: clinically important change ‒ not improved (CGI) compared with haloperidol continuation (very low certainty).

1 finding from 1 review

CBT plus standard care vs usual care

Global state: 2. Clinically important change (no improvement) ‐ long term · patients with schizophrenia

It is very uncertain whether COMPARISON 1: CBT+ STANDARD CARE changes global state: 2. Clinically important change (no improvement) ‐ long… compared with STANDARD CARE ALONE (very low certainty).

1 finding from 1 review