Cochrane · systematic review · CD011810
Chlorpromazine versus clotiapine for schizophrenia
Mazhari, S, Esmailian, S, Shah‐Esmaeili, A, et al. · Cochrane Database of Systematic Reviews · 2017 · Cochrane Library
SchizophreniaAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
7
current version
GRADE rated
4
No studies
3
Included studies
NR
No studies 3 · 42.9%Ungraded 0 · 0%Very low 4 · 57.1%Low 0 · 0%Moderate 0 · 0%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Chlorpromazine compared to Clotiapine for schizophrenia
Population: people with schizophrenia
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Global state: clinically important change Chlorpromazine vs Clotiapine | no estimate extracted | NR | No studies |
Mental state: 1a. General symptoms ‐ average change (PANSS, short term) Chlorpromazine vs Clotiapine | no estimate extracted | 1 study · 31 participants | Very low Downgraded: risk of bias, imprecision, indirectness |
Mental state: 2c. Specific ‐ average change score for negative symptoms (PANSS ‐ negative short term) Chlorpromazine vs Clotiapine | no estimate extracted | 1 study · 21 participants | Very low Downgraded: risk of bias, imprecision, publication bias |
Adverse effects: incidence of serious adverse effects. Movement disorders ‐ dyskinesia ‐short‐term Chlorpromazine vs Clotiapine | RR 3 [0.13, 71.15] | 1 study · 68 participants | Very low Downgraded: risk of bias, imprecision, publication bias |
Adverse effects: clinically significant extrapyramidal symptoms Chlorpromazine vs Clotiapine | no estimate extracted | NR | No studies |
Leaving the study early: for any reason Chlorpromazine vs Clotiapine | RR 0.68 [0.24, 1.88] | 3 studies · 158 participants | Very low Downgraded: risk of bias, imprecision, inconsistency |
Cost of care Chlorpromazine vs Clotiapine | no estimate extracted | NR | No studies |