Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

334 questions · 707 findings · 50 reviews

No studies found 3 · 0.4%GRADE not reported 667 · 94.3%Very low 31 · 4.4%Low 4 · 0.6%Moderate 2 · 0.3%High 0 · 0%

History of toothache vs No history of toothache

Dental caries · Primary school children in Ethiopia

A history of toothache was associated with higher odds of dental caries (OR 2.99, 95% CI 2.679-3.314; ungraded).

1 finding from 1 review

C allele vs A allele

Dental caries · Children (<18 years) with vs without dental caries

ApaI(rs7975232) allelic model: C vs A was not significantly associated with dental caries (OR 0.89); ungraded.

1 finding from 1 review

TT+CC (homozygous) genotypes vs CT (heterozygous) genotype

Dental caries · Children (<18 years) with vs without dental caries

Over-dominant model (CC+TT vs CT) at FokI(rs10735810) showed no significant association with caries (OR 0.83); ungraded.

1 finding from 1 review

A allele vs G allele

Dental caries · Children (<18 years) with vs without dental caries

FokI(rs2228570) allelic model: A vs G was not significantly associated with dental caries (OR 1.07); ungraded.

1 finding from 1 review

Vitamin D deficiency (serum 25(OH)D < 50 nmol/L) vs Normal vitamin D level (serum 25(OH)D ≥ 50 nmol/L)

Dental caries · Children (<19 years)

Children with vitamin D deficiency had a 22% higher risk of dental caries than those with normal vitamin D levels (unadjusted RR 1.22; ungraded).

5 findings from 1 review
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Vitamin D deficiency (serum 25(OH)D < 50 nmol/L) vs Normal vitamin D level (serum 25(OH)D ≥ 50 nmol/L)

Dental caries · Children with permanent dentition (>12 years)

In children with permanent dentition, vitamin D deficiency was associated with a 28% higher caries risk (RR 1.28; ungraded).

1 finding from 1 review

Vitamin D deficiency (serum 25(OH)D < 50 nmol/L) vs Normal vitamin D level (serum 25(OH)D ≥ 50 nmol/L)

Dental caries · Children with deciduous dentition (<6 years)

In children with deciduous dentition, vitamin D deficiency was associated with a 68% higher caries risk (RR 1.68; ungraded).

1 finding from 1 review

Vitamin D deficiency (serum 25(OH)D < 50 nmol/L) vs Normal vitamin D level (serum 25(OH)D ≥ 50 nmol/L)

Dental caries · Children (mixed dentition; baseline about 8 years)

In children with mixed dentition, vitamin D deficiency was associated with an 8% higher caries risk (RR 1.08; ungraded).

1 finding from 1 review

Food and nonalcoholic beverage marketing (exposure) vs No, less, or less powerful food marketing

Dental caries · Children and adolescents (general population, aged under 20 years)

Evidence on food marketing and dental caries is very uncertain (very low certainty); 1 of 2 studies found an association.

1 finding from 1 review

Food marketing exposure or greater marketing power vs No, less, or less powerful food marketing

Dental caries · Children and adolescents (general population, aged under 20 years)

Across two studies, 50% showed any association of potential public health harm for dental caries (very low certainty).

1 finding from 1 review

Multiple LTF gene variants (joint / gene-based) vs Caries-free controls

Dental caries · Individuals assessed for dental caries (cases with caries/high caries vs. caries-free or low/very-low-caries controls)

A gene-based analysis indicated that multiple LTF variants were jointly associated with dental caries risk (weighted TPM P = 0.0007; no pooled effect estimate; ungraded).

1 finding from 1 review

rs1126478, co-dominant model (GA genotype) vs GG or AA genotype

Dental caries · Individuals assessed for dental caries (cases with caries/high caries vs. caries-free or low/very-low-caries controls)

rs1126478 showed no significant association with dental caries under a co-dominant model (OR 0.97, 95% CI 0.72 to 1.32; ungraded).

1 finding from 1 review

LTF rs11716497 variant vs Reference allele/genotype

Dental caries · Individuals assessed for dental caries (cases with caries/high caries vs. caries-free or low/very-low-caries controls)

LTF rs11716497 showed no significant association with dental caries in a single study (OR 1.04, 95% CI 0.90 to 1.21; ungraded).

1 finding from 1 review

LTF rs1126477 variant vs Reference allele/genotype

Dental caries · Individuals assessed for dental caries (cases with caries/high caries vs. caries-free or low/very-low-caries controls)

LTF rs11216477 was significantly associated with dental caries in a single study (OR 1.17, 95% CI 1.06 to 1.29; ungraded).

1 finding from 1 review

rs1126478, additive (per-allele) model vs A allele

Dental caries · Individuals assessed for dental caries (cases with caries/high caries vs. caries-free or low/very-low-caries controls)

The additive-model association remained non-significant after excluding the adult-data study (OR 1.47, 95% CI 0.92 to 2.35; ungraded).

2 findings from 1 review

G allele of LTF rs1126478 vs A allele

Dental caries · Individuals assessed for dental caries (cases with caries/high caries vs. caries-free or low/very-low-caries controls)

rs1126478 showed no significant association with dental caries under an allelic model (OR 1.41, 95% CI 0.48 to 4.13; ungraded).

1 finding from 1 review

GG genotype of LTF rs1126478 vs GA+AA genotypes

Dental caries · Individuals assessed for dental caries (cases with caries/high caries vs. caries-free or low/very-low-caries controls)

rs1126478 showed no significant association with dental caries under a recessive model (OR 1.55, 95% CI 0.44 to 5.38; ungraded).

1 finding from 1 review

AG + GG genotype (G-allele carriers) of LTF rs1126478 vs AA genotype

Dental caries · Individuals assessed for dental caries (cases with caries/high caries vs. caries-free or low/very-low-caries controls)

rs1126478 showed no significant association with dental caries under a dominant model (OR 1.32, 95% CI 0.43 to 4.03; ungraded).

1 finding from 1 review

LTF rs6441989 variant vs Reference allele/genotype

Dental caries · Individuals assessed for dental caries (cases with caries/high caries vs. caries-free or low/very-low-caries controls)

LTF rs6441989 showed no significant association with dental caries in a single study (OR 1.02, 95% CI 0.92 to 1.14; ungraded).

1 finding from 1 review