Question · asked by 1 review
AG + GG genotype (G-allele carriers) of LTF rs1126478 vs AA genotype: Dental caries
- Population
- Individuals assessed for dental caries (cases with caries/high caries vs. caries-free or low/very-low-caries controls)
- Intervention
- AG + GG genotype (G-allele carriers) of LTF rs1126478
- Comparison
- AA genotype
- Outcome
- Dental caries
rs1126478 showed no significant association with dental caries under a dominant model (OR 1.32, 95% CI 0.43 to 4.03; ungraded).
What each review found
Include earlier review versions| Finding | Effect | Studies | GRADE certainty |
|---|---|---|---|
rs1126478, dominant model (GG or GA genotype) vs AA genotype Dental caries · Human subjects with dental caries and caries-free controls · Brazil; United States; European countries; China, Dominant model (GG + GA vs. AA) rs1126478 showed no significant association with dental caries under a dominant model (OR 1.32, 95% CI 0.43 to 4.03; ungraded). The association between genetic variants in lactotransferrin and dental caries: a meta- and gene-based… (2020) All outcomes | OR 1.32 [0.43, 4.03] | 4 studies · 1802 participants | GRADE not reported |
Findings are shown side by side, never pooled across reviews.
The reviews
| Review | Searched up to | Included studies | AMSTAR 2 |
|---|---|---|---|
| The association between genetic variants in lactotransferrin and dental caries: a meta- and gene-based analysis. 2020 All outcomes | December 5, 2019 (papers published before this date) | 6 | Not applicable |
How reviews are matched to this question
Reviews word the same question differently. Four decision models (TypeSafe's Jev, Liquid AI's d1-ultra, SubQ Snap and Baseten's Elephant) judged each wording of the population, intervention, comparator and outcome against the others; two wordings count as the same when at least three of them agree and none clearly disagrees, and findings count as this question only when all four elements match. Timing, setting and subgroup never split a question: they are shown on each finding.