Question · asked by 1 review
LTF rs6441989 variant vs Reference allele/genotype: Dental caries
- Population
- Individuals assessed for dental caries (cases with caries/high caries vs. caries-free or low/very-low-caries controls)
- Intervention
- LTF rs6441989 variant
- Comparison
- Reference allele/genotype
- Outcome
- Dental caries
LTF rs6441989 showed no significant association with dental caries in a single study (OR 1.02, 95% CI 0.92 to 1.14; ungraded).
What each review found
Include earlier review versions| Finding | Effect | Studies | GRADE certainty |
|---|---|---|---|
LTF rs6441989 variant vs Reference allele/genotype Dental caries · Human subjects with dental caries and caries-free controls · Brazil, Single study (Doetzer et al. 2015) LTF rs6441989 showed no significant association with dental caries in a single study (OR 1.02, 95% CI 0.92 to 1.14; ungraded). The association between genetic variants in lactotransferrin and dental caries: a meta- and gene-based… (2020) All outcomes | OR 1.02 [0.92, 1.14] | 1 study · 677 participants | GRADE not reported |
Findings are shown side by side, never pooled across reviews.
The reviews
| Review | Searched up to | Included studies | AMSTAR 2 |
|---|---|---|---|
| The association between genetic variants in lactotransferrin and dental caries: a meta- and gene-based analysis. 2020 All outcomes | December 5, 2019 (papers published before this date) | 6 | Not applicable |
How reviews are matched to this question
Reviews word the same question differently. Four decision models (TypeSafe's Jev, Liquid AI's d1-ultra, SubQ Snap and Baseten's Elephant) judged each wording of the population, intervention, comparator and outcome against the others; two wordings count as the same when at least three of them agree and none clearly disagrees, and findings count as this question only when all four elements match. Timing, setting and subgroup never split a question: they are shown on each finding.