What do systematic reviews say?

51 questions · 53 findings · 13 reviews · HIV/AIDS

Sort:Best matchNewest Highest certainty Download CSV

No studies found 0 · 0%GRADE not reported 0 · 0%Very low 14 · 26.4%Low 8 · 15.1%Moderate 25 · 47.2%High 6 · 11.3%

Closest answers

The findings closest to your search, judged one by one by TypeSafe's Jev model.

Direct match · question page
- Recombinant Human Erythropoietin vs Placebo · Death
  Treatment for anemia in people with AIDS 2011 · Cochrane Headline outcomes only
  RR 0.56 [0.08, 4.05]
  2 studies · 84 participants
  Very low
Direct match · question page
- Early ART vs standard or deferred ART (CD4 <= 200 or CD4 <= 250 cells/µl) · Death
  Optimal time for initiation of antiretroviral therapy in asymptomatic, HIV‐infected, treatment‐naive adults 2010 · Cochrane Headline outcomes only
  RR 0.26 [0.11, 0.62]
  2 studies · 1065 participants
  Moderate
Direct match · question page
- Doctor vs community health worker · Death (RCTs)
  Task shifting from doctors to non‐doctors for initiation and maintenance of antiretroviral therapy 2014 · Cochrane Headline outcomes only
  RR 1 [0.62, 1.62]
  1 study · 559 participants
  Moderate
Direct match · question page
- Doctor vs nurse or clinical officer · Death (RCTs)
  Task shifting from doctors to non‐doctors for initiation and maintenance of antiretroviral therapy 2014 · Cochrane Headline outcomes only
  RR 0.89 [0.59, 1.32]
  2 studies · 4332 participants
  Moderate
Direct match · question page
- Doctor vs nurse or clinical officer · Death (Cohorts)
  Task shifting from doctors to non‐doctors for initiation and maintenance of antiretroviral therapy 2014 · Cochrane Headline outcomes only
  RR 0.19 [0.05, 0.78]
  1 study · 2772 participants
  Very low

Intervention not reported

Death · HIV infected patients

The intervention may leads to lower death (low certainty).

1 finding from 1 review

Decentralising HIV treatment in lower‐ and middle‐income countries 2013 · Cochrane Headline outcomes only
RR 0.34 [0.13, 0.87]
4 studies · 39090 participants
Low

Intervention not reported

Death · HIV infected patients

It is very uncertain whether the intervention changes death (very low certainty).

1 finding from 1 review

Decentralising HIV treatment in lower‐ and middle‐income countries 2013 · Cochrane Headline outcomes only
RR 1.1 [0.63, 1.92]
4 studies · 55099 participants
Very low

Intervention not reported

Death · HIV‐infected patients

The intervention showed no clear difference in death (moderate certainty).

1 finding from 1 review

Decentralising HIV treatment in lower‐ and middle‐income countries 2013 · Cochrane Headline outcomes only
RR 1.03 [0.64, 1.65]
2 studies · 709 participants
Moderate

IMMEDIATE initiation of cART vs DEFERRED initiation of cART

Death · HIV‐positive, treatment‐naive children aged one to 12 years old

It is very uncertain whether IMMEDIATE initiation of cART changes death compared with DEFERRED initiation of cART (very low certainty).

1 finding from 1 review

Optimal time for initiating antiretroviral therapy (ART) in HIV‐infected, treatment‐naive children aged 2 to 5 years old 2013 · Cochrane Headline outcomes only
RR 3 [0.12, 73.06]
2 studies · 343 participants
Very low

IMMEDIATE initiation of cART vs DEFERRED initiation of cART

Death · HIV‐positive, treatment‐naive children aged 24 to 59 months (2 to 5 years old)

It is very uncertain whether subgroup analysis: IMMEDIATE initiation of cART changes death compared with DEFERRED initiation of cART (very low certainty).

1 finding from 1 review

Optimal time for initiating antiretroviral therapy (ART) in HIV‐infected, treatment‐naive children aged 2 to 5 years old 2013 · Cochrane Headline outcomes only
RR 2.88 [0.12, 68.88]
2 studies · 122 participants
Very low

Erythropoietin vs placebo

Death · patients with anemia in people with AIDS

It is very uncertain whether recombinant Human Erythropoietin changes death compared with placebo (very low certainty).

1 finding from 1 review

Treatment for anemia in people with AIDS 2011 · Cochrane Headline outcomes only
RR 0.56 [0.08, 4.05]
2 studies · 84 participants
Very low

Early ART vs standard or deferred ART (CD4 <= 200 or CD4 <= 250 cells/µl)

Death · patients with asymptomatic, HIV‐infected, treatment naive adults

Early ART probably leads to lower death compared with standard or deferred ART (CD4 <= 200 or CD4 <= 250 cells/µl) (moderate certainty).

1 finding from 1 review

Optimal time for initiation of antiretroviral therapy in asymptomatic, HIV‐infected, treatment‐naive adults 2010 · Cochrane Headline outcomes only
RR 0.26 [0.11, 0.62]
2 studies · 1065 participants
Moderate

Doctor vs nurse or clinical officer

Death (RCTs) · HIV‐infected patients

Doctor showed no clear difference in death (RCTs) compared with nurse or clinical officer (high certainty).

1 finding from 1 review

Task shifting from doctors to non‐doctors for initiation and maintenance of antiretroviral therapy 2014 · Cochrane Headline outcomes only
RR 0.96 [0.82, 1.12]
1 study · 2770 participants
High

Doctor vs community health worker

Death (RCTs) · HIV infected patients on antiretroviral therapy

Doctor showed no clear difference in death (RCTs) compared with community health worker (moderate certainty).

1 finding from 1 review

Task shifting from doctors to non‐doctors for initiation and maintenance of antiretroviral therapy 2014 · Cochrane Headline outcomes only
RR 1 [0.62, 1.62]
1 study · 559 participants
Moderate

Doctor vs nurse or clinical officer

Death (RCTs) · HIV infected patients on antiretroviral therapy

Doctor showed no clear difference in death (RCTs) compared with nurse or clinical officer (moderate certainty).

1 finding from 1 review

Task shifting from doctors to non‐doctors for initiation and maintenance of antiretroviral therapy 2014 · Cochrane Headline outcomes only
RR 0.89 [0.59, 1.32]
2 studies · 4332 participants
Moderate

Doctor vs nurse or clinical officer

Death (Cohorts) · HIV‐infected patients

Doctor may leads to higher death (Cohorts) compared with nurse or clinical officer (low certainty).

1 finding from 1 review

Task shifting from doctors to non‐doctors for initiation and maintenance of antiretroviral therapy 2014 · Cochrane Headline outcomes only
RR 1.23 [1.14, 1.33]
2 studies · 39160 participants
Low

Doctor vs nurse or clinical officer

Death (Cohorts) · HIV infected patients on antiretroviral therapy

It is very uncertain whether doctor changes death (Cohorts) compared with nurse or clinical officer (very low certainty).

1 finding from 1 review

Task shifting from doctors to non‐doctors for initiation and maintenance of antiretroviral therapy 2014 · Cochrane Headline outcomes only
RR 0.19 [0.05, 0.78]
1 study · 2772 participants
Very low

Intervention not reported

Perinatal death · Pregnant women with HIV infection

The intervention showed no clear difference in perinatal death (moderate certainty).

1 finding from 1 review

Micronutrient supplementation in pregnant women with HIV infection 2012 · Cochrane Headline outcomes only
RR 1.36 [0.75, 2.47]
1 study · 397 participants
Moderate

Intervention not reported

Perinatal death · Pregnant women with HIV infection

The intervention showed no clear difference in perinatal death (moderate certainty).

1 finding from 1 review

Micronutrient supplementation in pregnant women with HIV infection 2012 · Cochrane Headline outcomes only
RR 0.77 [0.48, 1.23]
1 study · 1115 participants
Moderate

Doctor vs nurse or clinical officer

Death or loss to · HIV infected patients on antiretroviral therapy

Doctor showed no clear difference in death or loss to compared with nurse or clinical officer (moderate certainty).

2 findings from 1 review

Task shifting from doctors to non‐doctors for initiation and maintenance of antiretroviral therapy 2014 · Cochrane Headline outcomes only
RR 1.1 [0.86, 1.41]
2 studies · 4332 participants
Moderate
Task shifting from doctors to non‐doctors for initiation and maintenance of antiretroviral therapy 2014 · Cochrane Headline outcomes only
RR 0.3 [0.17, 0.54]
1 study · 2772 participants
Very low

Doctor vs community health worker

Death or lost to · HIV infected patients on antiretroviral therapy

Doctor showed no clear difference in death or lost to compared with community health worker (moderate certainty).

1 finding from 1 review

Task shifting from doctors to non‐doctors for initiation and maintenance of antiretroviral therapy 2014 · Cochrane Headline outcomes only
RR 0.93 [0.6, 1.46]
1 study · 559 participants
Moderate

Doctor vs nurse or clinical officer

Death or loss to · HIV‐infected patients

Doctor showed no clear difference in death or loss to compared with nurse or clinical officer (high certainty).

2 findings from 1 review

Task shifting from doctors to non‐doctors for initiation and maintenance of antiretroviral therapy 2014 · Cochrane Headline outcomes only
RR 0.89 [0.79, 1.01]
1 study · 2770 participants
High
Task shifting from doctors to non‐doctors for initiation and maintenance of antiretroviral therapy 2014 · Cochrane Headline outcomes only
RR 0.72 [0.48, 1.07]
2 studies · 39160 participants
Very low

Intervention not reported

Death (all cause) · HIV infected adults who meet the WHO criteria for commencing antiretroviral treatment.

The intervention showed no clear difference in death (all cause) (low certainty).

1 finding from 1 review

Effectiveness and safety of first-line tenofovir + emtricitabine + efavirenz for patients with HIV 2012 · Cochrane Headline outcomes only
RR 0.5 [0.05, 5.46]
1 study · 487 participants
Low

Intervention not reported

Death or lost to care · HIV infected patients

The intervention probably leads to lower death or lost to care (moderate certainty).

1 finding from 1 review

Decentralising HIV treatment in lower‐ and middle‐income countries 2013 · Cochrane Headline outcomes only
RR 0.46 [0.29, 0.71]
4 studies · 39090 participants
Moderate

Intervention not reported

Death or lost to care · HIV infected patients

It is very uncertain whether the intervention changes death or lost to care (very low certainty).

1 finding from 1 review

Decentralising HIV treatment in lower‐ and middle‐income countries 2013 · Cochrane Headline outcomes only
RR 0.7 [0.47, 1.02]
4 studies · 56360 participants
Very low