Cochrane · systematic review · CD010309
Optimal time for initiating antiretroviral therapy (ART) in HIV‐infected, treatment‐naive children aged 2 to 5 years old
Siegfried, N, Davies, MA, Penazzato, M, et al. · Cochrane Database of Systematic Reviews · 2013 · Cochrane Library
HIV/AIDSAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
15
current version
GRADE rated
14
No studies
1
Included studies
NR
No studies 1 · 6.7%Ungraded 0 · 0%Very low 10 · 66.7%Low 4 · 26.7%Moderate 0 · 0%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
IMMEDIATE initiation of cART compared to DEFERRED initiation of cART for HIV‐positive, treatment‐naive children aged one to 12 years old
Population: HIV‐positive, treatment‐naive children aged one to 12 years old
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Death IMMEDIATE initiation of cART vs DEFERRED initiation of cART | RR 3 [0.12, 73.06] | 2 studies · 343 participants | Very low Downgraded: risk of bias, imprecision |
CDC Category C disease (number of children) IMMEDIATE initiation of cART vs DEFERRED initiation of cART | RR 1.5 [0.25, 8.85] | 2 studies · 343 participants | Very low Downgraded: risk of bias, imprecision |
CDC Category B disease (numbers of children) Peto Odds Ratio IMMEDIATE initiation of cART vs DEFERRED initiation of cART | OR 0.7 [0.39, 1.24] | 2 studies · 343 participants | Very low Downgraded: risk of bias, imprecision, inconsistency |
Proportion of children on ART with HIV‐RNA < 50 copies/ml (Copy) IMMEDIATE initiation of cART vs DEFERRED initiation of cART | RR 0.96 [0.84, 1.09] | 2 studies · 238 participants | Low Downgraded: risk of bias, imprecision |
Weight gain per year in kg IMMEDIATE initiation of cART vs DEFERRED initiation of cART | no estimate extracted | 1 study · 300 participants | Low Downgraded: risk of bias, imprecision |
Height gain per year in cm IMMEDIATE initiation of cART vs DEFERRED initiation of cART | no estimate extracted | 1 study · 300 participants | Low Downgraded: risk of bias, imprecision |
Standardized score on Beery VMI at 144 weeks IMMEDIATE initiation of cART vs DEFERRED initiation of cART | no estimate extracted | 1 study · 272 participants | Low Downgraded: risk of bias, imprecision |
Patient or population: HIV‐positive, treatment‐naive children aged 24 to 59 months (2 to 5 years old)Settings: Thailand and CambodiaIntervention: IMMEDIATE initiation of cARTComparison: DEFERRED initiation of cART IMMEDIATE initiation of cART vs DEFERRED initiation of cART | no estimate extracted | NR | No studies |
Subgroup analysis: IMMEDIATE initiation of cART compared to DEFERRED initiation of cART for HIV‐positive, treatment‐naive children aged 24 to 59 months (2 to 5 years old)
Population: HIV‐positive, treatment‐naive children aged 24 to 59 months (2 to 5 years old)
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Death Subgroup analysis: IMMEDIATE initiation of cART vs DEFERRED initiation of cART | RR 2.88 [0.12, 68.88] | 2 studies · 122 participants | Very low Downgraded: risk of bias, imprecision |
CDC Category C disease (number of children) Subgroup analysis: IMMEDIATE initiation of cART vs DEFERRED initiation of cART | RR 0.96 [0.06, 14.87] | 2 studies · 122 participants | Very low Downgraded: risk of bias, imprecision |
CDC Category B disease (numbers of children) Peto Odds Ratio Subgroup analysis: IMMEDIATE initiation of cART vs DEFERRED initiation of cART | OR 0.64 [0.24, 1.75] | 1 study · 94 participants | Very low Downgraded: risk of bias, imprecision |
Proportion of children on ART with HIV‐RNA < 50 copies/ml Subgroup analysis: IMMEDIATE initiation of cART vs DEFERRED initiation of cART | RR 1.11 [0.86, 1.43] | 1 study · 67 participants | Very low Downgraded: imprecision |
Mean weight gain per year in kg Subgroup analysis: IMMEDIATE initiation of cART vs DEFERRED initiation of cART | no estimate extracted | 1 study · 94 participants | Very low Downgraded: risk of bias, imprecision |
Mean height gain per year in cm Subgroup analysis: IMMEDIATE initiation of cART vs DEFERRED initiation of cART | no estimate extracted | 1 study · 94 participants | Very low Downgraded: risk of bias, imprecision |
Mean standardized score on Beery VMI at 144 weeks Subgroup analysis: IMMEDIATE initiation of cART vs DEFERRED initiation of cART | no estimate extracted | 1 study · 82 participants | Very low Downgraded: risk of bias, imprecision |