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What do systematic reviews say?

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Evidence found and GRADE certainty

18 questions · 18 findings · 8 reviews · Hypertension

No studies found 0 · 0%GRADE not reported 0 · 0%Very low 4 · 22.2%Low 6 · 33.3%Moderate 3 · 16.7%High 5 · 27.8%

Evening vs morning dosing regimen

All‐cause mortality · adults with primary (essential) hypertension whose systolic or diastolic (or both) blood pressure levels were 130/80 mmHg or greater

It is very uncertain whether evening changes all‐cause mortality compared with morning dosing regimen (very low certainty).

1 finding from 1 review

Antihypertensive drug therapy vs placebo or no treatment

All‐cause mortality · adults (18 years of age or older) with hypertension‐induced left ventricular hypertrophy

It is very uncertain whether antihypertensive therapy changes all‐cause mortality compared with placebo or no treatment (very low certainty).

1 finding from 1 review

Intervention not reported

All‐cause mortality at 2 days ‐ immediate treatment · patients with acute myocardial infarction or stroke1

It is very uncertain whether the intervention changes all‐cause mortality at 2 days ‐ immediate treatment (very low certainty).

1 finding from 1 review

Intervention not reported

All‐cause mortality at 10 days ‐ short‐term treatment · patients with acute myocardial infarction or stroke1

It is very uncertain whether the intervention changes all‐cause mortality at 10 days ‐ short‐term treatment (very low certainty).

1 finding from 1 review