Cochrane · systematic review · CD012572
Withdrawal of antihypertensive drugs in older people
Reeve, E, Jordan, V, Thompson, W, et al. · Cochrane Database of Systematic Reviews · 2020 · Cochrane Library
HypertensionAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
8
current version
GRADE rated
7
No studies
1
Included studies
NR
No studies 1 · 12.5%Ungraded 0 · 0%Very low 2 · 25%Low 5 · 62.5%Moderate 0 · 0%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Discontinuation by no treatment/placebo of antihypertensives compared to continuation in older people
Population: Older adults, 50 years and older
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
All‐cause mortality Discontinuation by no treatment/placebo of antihypertensives vs continuation | OR 2.08 [0.79, 5.46] | 4 studies · 630 participants | Low Downgraded: risk of bias |
Myocardial infarction (fatal and nonfatal) Discontinuation by no treatment/placebo of antihypertensives vs continuation | OR 1.86 [0.19, 17.98] | 2 studies · 447 participants | Very low Downgraded: risk of bias, imprecision, inconsistency, indirectness |
Hospitalisation Discontinuation by no treatment/placebo of antihypertensives vs continuation | OR 0.83 [0.33, 2.1] | 1 study · 385 participants | Low Downgraded: risk of bias, imprecision, inconsistency, indirectness |
Stroke (fatal + nonfatal + TIA) Discontinuation by no treatment/placebo of antihypertensives vs continuation | OR 1.44 [0.25, 8.35] | 3 studies · 524 participants | Low Downgraded: risk of bias, imprecision, inconsistency, indirectness |
Systolic blood pressure Discontinuation by no treatment/placebo of antihypertensives vs continuation | no estimate extracted | 5 studies · 767 participants | Low Downgraded: risk of bias, imprecision, inconsistency, indirectness |
Diastolic blood pressure: range 12 weeks to 12 months Discontinuation by no treatment/placebo of antihypertensives vs continuation | no estimate extracted | 5 studies · 768 participants | Low Downgraded: risk of bias, imprecision, inconsistency, indirectness |
Adverse drug reactions and adverse drug withdrawal reactions (adverse reactions) Discontinuation by no treatment/placebo of antihypertensives vs continuation | no estimate extracted | 3 studies · 245 participants | Very low Downgraded: risk of bias, imprecision, inconsistency, indirectness |
Falls ‐ not reported Discontinuation by no treatment/placebo of antihypertensives vs continuation | no estimate extracted | NR | No studies |